Stochastic Mechanisms of Cell-Size Regulation in Bacteria

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dc.citation.firstpage8777en_US
dc.citation.issueNumber20en_US
dc.citation.journalTitleThe Journal of Physical Chemistry Lettersen_US
dc.citation.lastpage8782en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorTeimouri, Hamiden_US
dc.contributor.authorMukherjee, Rupshaen_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2020-11-11T20:20:28Zen_US
dc.date.available2020-11-11T20:20:28Zen_US
dc.date.issued2020en_US
dc.description.abstractHow bacteria are able to maintain their sizes remains an open question. It is believed that cells have narrow distributions of sizes as a consequence of a homeostasis that allows bacteria to function at the optimal conditions. Several phenomenological approaches to explain these observations have been presented, but the microscopic origins of the cell-size regulation are still not understood. Here, we propose a new stochastic approach to investigate the molecular mechanisms of maintaining the cell sizes in bacteria. It is argued that the cell-size regulation is a result of coupling of two stochastic processes, cell growth and division, which eliminates the need for introducing the thresholds. Dynamic properties of the system are explicitly evaluated, and it is shown that the model is consistent with the experimentally supported adder principle of the cell-size regulation. In addition, theoretical predictions agree with experimental observations on E. coli bacteria. Theoretical analysis clarifies some important features of bacterial cell growth.en_US
dc.identifier.citationTeimouri, Hamid, Mukherjee, Rupsha and Kolomeisky, Anatoly B.. "Stochastic Mechanisms of Cell-Size Regulation in Bacteria." <i>The Journal of Physical Chemistry Letters,</i> 11, no. 20 (2020) American Chemical Society: 8777-8782. https://doi.org/10.1021/acs.jpclett.0c02627.en_US
dc.identifier.doihttps://doi.org/10.1021/acs.jpclett.0c02627en_US
dc.identifier.urihttps://hdl.handle.net/1911/109548en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.titleStochastic Mechanisms of Cell-Size Regulation in Bacteriaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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