Can we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?

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dc.citation.articleNumber27001
dc.citation.issueNumber2
dc.citation.journalTitleEurophysics Letters
dc.citation.volumeNumber137
dc.contributor.authorTeimouri, Hamid
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2022-05-25T14:49:59Z
dc.date.available2022-05-25T14:49:59Z
dc.date.issued2022
dc.description.abstractCancer is a collection of related genetic diseases exhibiting uncontrolled cell growth that interferes with normal functioning of human organisms. It results from accumulation of unfavorable mutations in tissues. While the biochemical picture of how cancer appears is known, the molecular mechanisms of tumor formation remain not fully understood despite tremendous efforts of researchers in multiple fields. New approaches for investigating cancer are constantly sought. In this paper, we discuss a powerful method of clarifying better a more microscopic picture of cancer by analyzing the dynamics of tumor formation. Using physics- and chemistry-inspired discrete-state stochastic description of cancer initiation, it is shown how the mechanisms of tumor formation can be uncovered. This approach is suggested as a powerful new physical-chemical tool for a better understanding of complex processes associated with cancer.
dc.identifier.citationTeimouri, Hamid and Kolomeisky, Anatoly B.. "Can we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?." <i>Europhysics Letters,</i> 137, no. 2 (2022) IOP Publishing: https://doi.org/10.1209/0295-5075/ac5ddc.
dc.identifier.doihttps://doi.org/10.1209/0295-5075/ac5ddc
dc.identifier.urihttps://hdl.handle.net/1911/112399
dc.language.isoeng
dc.publisherIOP Publishing
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.
dc.titleCan we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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