Can we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?

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dc.citation.articleNumber27001en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitleEurophysics Lettersen_US
dc.citation.volumeNumber137en_US
dc.contributor.authorTeimouri, Hamiden_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2022-05-25T14:49:59Zen_US
dc.date.available2022-05-25T14:49:59Zen_US
dc.date.issued2022en_US
dc.description.abstractCancer is a collection of related genetic diseases exhibiting uncontrolled cell growth that interferes with normal functioning of human organisms. It results from accumulation of unfavorable mutations in tissues. While the biochemical picture of how cancer appears is known, the molecular mechanisms of tumor formation remain not fully understood despite tremendous efforts of researchers in multiple fields. New approaches for investigating cancer are constantly sought. In this paper, we discuss a powerful method of clarifying better a more microscopic picture of cancer by analyzing the dynamics of tumor formation. Using physics- and chemistry-inspired discrete-state stochastic description of cancer initiation, it is shown how the mechanisms of tumor formation can be uncovered. This approach is suggested as a powerful new physical-chemical tool for a better understanding of complex processes associated with cancer.en_US
dc.identifier.citationTeimouri, Hamid and Kolomeisky, Anatoly B.. "Can we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?." <i>Europhysics Letters,</i> 137, no. 2 (2022) IOP Publishing: https://doi.org/10.1209/0295-5075/ac5ddc.en_US
dc.identifier.doihttps://doi.org/10.1209/0295-5075/ac5ddcen_US
dc.identifier.urihttps://hdl.handle.net/1911/112399en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.en_US
dc.titleCan we understand the mechanisms of tumor formation by analyzing dynamics of cancer initiation?en_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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