Quasispecies theory for evolution of modularity

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dc.citation.firstpage12714en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitlePhysical Review Een_US
dc.citation.volumeNumber91en_US
dc.contributor.authorPark, Jeong-Manen_US
dc.contributor.authorNiestemski, Liang Renen_US
dc.contributor.authorDeem, Michael W.en_US
dc.date.accessioned2016-02-05T18:38:32Zen_US
dc.date.available2016-02-05T18:38:32Zen_US
dc.date.issued2015en_US
dc.description.abstractBiological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a quasispecies theory for the dynamics of modularity in populations of these systems. We show how the steady-state fitness in a randomly changing environment can be computed. We derive a fluctuation dissipation relation for the rate of change of modularity and use it to derive a relationship between rate of environmental changes and rate of growth of modularity. We also find a principle of least action for the evolved modularity at steady state. Finally, we compare our predictions to simulations of protein evolution and find them to be consistent.en_US
dc.identifier.citationPark, Jeong-Man, Niestemski, Liang Ren and Deem, Michael W.. "Quasispecies theory for evolution of modularity." <i>Physical Review E,</i> 91, no. 1 (2015) American Physical Society: 012714. http://dx.doi.org/10.1103/PhysRevE.91.012714.en_US
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.91.012714en_US
dc.identifier.urihttps://hdl.handle.net/1911/88398en_US
dc.language.isoengen_US
dc.publisherAmerican Physical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleQuasispecies theory for evolution of modularityen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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