Quasispecies theory for evolution of modularity

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2015
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American Physical Society
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Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a quasispecies theory for the dynamics of modularity in populations of these systems. We show how the steady-state fitness in a randomly changing environment can be computed. We derive a fluctuation dissipation relation for the rate of change of modularity and use it to derive a relationship between rate of environmental changes and rate of growth of modularity. We also find a principle of least action for the evolved modularity at steady state. Finally, we compare our predictions to simulations of protein evolution and find them to be consistent.

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Park, Jeong-Man, Niestemski, Liang Ren and Deem, Michael W.. "Quasispecies theory for evolution of modularity." Physical Review E, 91, no. 1 (2015) American Physical Society: 012714. http://dx.doi.org/10.1103/PhysRevE.91.012714.

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