Theoretical investigation of stochastic clearance of bacteria: first-passage analysis

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dc.citation.issueNumber152
dc.citation.journalTitleJournal of the Royal Society Interface
dc.citation.volumeNumber16
dc.contributor.authorTeimouri, Hamid
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2019-08-12T14:50:00Z
dc.date.available2019-08-12T14:50:00Z
dc.date.issued2019
dc.description.abstractUnderstanding mechanisms of bacterial eradication is critically important for overcoming failures of antibiotic treatments. Current studies suggest that the clearance of large bacterial populations proceeds deterministically, while for smaller populations, the stochastic effects become more relevant. Here, we develop a theoretical approach to investigate the bacterial population dynamics under the effect of antibiotic drugs using a method of first-passage processes. It allows us to explicitly evaluate the most important characteristics of bacterial clearance dynamics such as extinction probabilities and extinction times. The new meaning of minimal inhibitory concentrations for stochastic clearance of bacterial populations is also discussed. In addition, we investigate the effect of fluctuations in population growth rates on the dynamics of bacterial eradication. It is found that extinction probabilities and extinction times generally do not correlate with each other when random fluctuations in the growth rates are taking place. Unexpectedly, for a significant range of parameters, the extinction times increase due to these fluctuations, indicating a slowing in the bacterial clearance dynamics. It is argued that this might be one of the initial steps in the pathway for the development of antibiotic resistance. Furthermore, it is suggested that extinction times is a convenient measure of bacterial tolerance.
dc.identifier.citationTeimouri, Hamid and Kolomeisky, Anatoly B.. "Theoretical investigation of stochastic clearance of bacteria: first-passage analysis." <i>Journal of the Royal Society Interface,</i> 16, no. 152 (2019) The Royal Society: https://doi.org/10.1098/rsif.2018.0765.
dc.identifier.doihttps://doi.org/10.1098/rsif.2018.0765
dc.identifier.urihttps://hdl.handle.net/1911/106210
dc.language.isoeng
dc.publisherThe Royal Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the authors.
dc.subject.keywordantibiotic resistance
dc.subject.keywordextinction probability
dc.subject.keywordextinction time
dc.subject.keywordstochastic clearance
dc.titleTheoretical investigation of stochastic clearance of bacteria: first-passage analysis
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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