Discrete-state stochastic kinetic models for target DNA search by proteins: Theory and experimental applications

Simple item page
dc.citation.articleNumber106521
dc.citation.journalTitleBiophysical Chemistry
dc.citation.volumeNumber269
dc.contributor.authorIwahara, Junji
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2021-02-08T18:38:02Z
dc.date.available2021-02-08T18:38:02Z
dc.date.issued2021
dc.description.abstractTo perform their functions, transcription factors and DNA-repair/modifying enzymes randomly search DNA in order to locate their specific targets on DNA. Discrete-state stochastic kinetic models have been developed to explain how the efficiency of the search process is influenced by the molecular properties of proteins and DNA as well as by other factors such as molecular crowding. These theoretical models not only offer explanations on the relation of microscopic processes to macroscopic behavior of proteins, but also facilitate the analysis and interpretation of experimental data. In this review article, we provide an overview on discrete-state stochastic kinetic models and explain how these models can be applied to experimental investigations using stopped-flow, single-molecule, nuclear magnetic resonance (NMR), and other biophysical and biochemical methods.
dc.identifier.citationIwahara, Junji and Kolomeisky, Anatoly B.. "Discrete-state stochastic kinetic models for target DNA search by proteins: Theory and experimental applications." <i>Biophysical Chemistry,</i> 269, (2021) Elsevier: https://doi.org/10.1016/j.bpc.2020.106521.
dc.identifier.digitalstochastic-kinetic-models
dc.identifier.doihttps://doi.org/10.1016/j.bpc.2020.106521
dc.identifier.urihttps://hdl.handle.net/1911/109826
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordDiffusion
dc.subject.keywordDynamics
dc.subject.keywordKinetics
dc.subject.keywordProtein-DNA interactions
dc.subject.keywordTarget search
dc.titleDiscrete-state stochastic kinetic models for target DNA search by proteins: Theory and experimental applications
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
stochastic-kinetic-models.pdf
Size:
5.04 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemical and Biomolecular Engineering Publications
Chemistry Publications
Physics and Astronomy Publications