Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

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2018
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Springer
Abstract

Purpose of Review: To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk. Recent Findings: Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality. Summary: Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.

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Seiler, Annina, Chen, Michelle A., Brown, Ryan L., et al.. "Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk." Current Breast Cancer Reports, 10, no. 1 (2018) Springer: 14-27. https://doi.org/10.1007/s12609-018-0264-0.

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