Cooperativity in Bacterial Membrane Association Controls the Synergistic Activities of Antimicrobial Peptides

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dc.citation.firstpage7365
dc.citation.issueNumber38
dc.citation.journalTitleThe Journal of Physical Chemistry B
dc.citation.lastpage7372
dc.citation.volumeNumber126
dc.contributor.authorNguyen, Thao N.
dc.contributor.authorTeimouri, Hamid
dc.contributor.authorMedvedeva, Angela
dc.contributor.authorKolomeisky, Anatoly B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2022-11-03T14:38:38Z
dc.date.available2022-11-03T14:38:38Z
dc.date.issued2022
dc.description.abstractAntimicrobial peptides (AMPs), or defence peptides, are compounds naturally produced during immune responses of living organisms against bacterial infections that are currently actively considered as promising alternatives to antibiotics. Recent experimental studies uncovered that in many situations, combinations of different AMPs are much more successful in eliminating the bacterial pathogens than single peptide species. However, the microscopic origin of such synergistic activities remains not fully understood. We present and investigate a possible mechanism of synergy between AMPs. It is based on the idea that due to inter-molecular interactions, the presence of an AMP of one type stimulates the association of an AMP of another type, and this accelerates the overall association to the membrane, eventually killing the bacteria. This approach allows us to fully quantify the synergistic activities of AMPs, and it is successfully applied for several experimental systems. It is found that strong cooperativity can be achieved for relatively weak inter-molecular interactions, suggesting that the application of combinations of AMPs can be further rationally optimized to make it a powerful antibacterial treatment.
dc.identifier.citationNguyen, Thao N., Teimouri, Hamid, Medvedeva, Angela, et al.. "Cooperativity in Bacterial Membrane Association Controls the Synergistic Activities of Antimicrobial Peptides." <i>The Journal of Physical Chemistry B,</i> 126, no. 38 (2022) American Chemical Society: 7365-7372. https://doi.org/10.1021/acs.jpcb.2c05345.
dc.identifier.doihttps://doi.org/10.1021/acs.jpcb.2c05345
dc.identifier.urihttps://hdl.handle.net/1911/113787
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.titleCooperativity in Bacterial Membrane Association Controls the Synergistic Activities of Antimicrobial Peptides
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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