Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

Simple item page
dc.citation.articleNumber1668
dc.citation.journalTitleScientific Reports
dc.citation.volumeNumber3
dc.contributor.authorSchultz, Daniel
dc.contributor.authorLu, Mingyang
dc.contributor.authorStavropoulos, Trevor
dc.contributor.authorOnuchic, José
dc.contributor.authorBen-Jacob, Eshel
dc.date.accessioned2017-07-31T18:12:33Z
dc.date.available2017-07-31T18:12:33Z
dc.date.issued2013
dc.description.abstractSporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.
dc.identifier.citationSchultz, Daniel, Lu, Mingyang, Stavropoulos, Trevor, et al.. "Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate." <i>Scientific Reports,</i> 3, (2013) Nature Publishing Group: http://dx.doi.org/10.1038/srep01668.
dc.identifier.digitalTurning_Oscillations_Into_Opportunities
dc.identifier.doihttp://dx.doi.org/10.1038/srep01668
dc.identifier.urihttps://hdl.handle.net/1911/95631
dc.language.isoeng
dc.publisherNature Publishing Group
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.titleTurning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Oscillations_Opportunities.pdf
Size:
3.44 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Physics and Astronomy Publications