Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

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dc.citation.articleNumber1668en_US
dc.citation.journalTitleScientific Reportsen_US
dc.citation.volumeNumber3en_US
dc.contributor.authorSchultz, Danielen_US
dc.contributor.authorLu, Mingyangen_US
dc.contributor.authorStavropoulos, Trevoren_US
dc.contributor.authorOnuchic, Joséen_US
dc.contributor.authorBen-Jacob, Eshelen_US
dc.date.accessioned2017-07-31T18:12:33Zen_US
dc.date.available2017-07-31T18:12:33Zen_US
dc.date.issued2013en_US
dc.description.abstractSporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.en_US
dc.identifier.citationSchultz, Daniel, Lu, Mingyang, Stavropoulos, Trevor, et al.. "Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate." <i>Scientific Reports,</i> 3, (2013) Nature Publishing Group: http://dx.doi.org/10.1038/srep01668.en_US
dc.identifier.digitalTurning_Oscillations_Into_Opportunitiesen_US
dc.identifier.doihttp://dx.doi.org/10.1038/srep01668en_US
dc.identifier.urihttps://hdl.handle.net/1911/95631en_US
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.titleTurning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gateen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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