Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate

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2013
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Nature Publishing Group
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Sporulation vs. competence provides a prototypic example of collective cell fate determination. The decision is performed by the action of three modules: 1) A stochastic competence switch whose transition probability is regulated by population density, population stress and cell stress. 2) A sporulation timer whose clock rate is regulated by cell stress and population stress. 3) A decision gate that is coupled to the timer via a special repressilator-like loop. We show that the distinct circuit architecture of this gate leads to special dynamics and noise management characteristics: The gate opens a time-window of opportunity for competence transitions during which it generates oscillations that are turned into a chain of transition opportunities – each oscillation opens a short interval with high transition probability. The special architecture of the gate also leads to filtering of external noise and robustness against internal noise and variations in the circuit parameters.

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Schultz, Daniel, Lu, Mingyang, Stavropoulos, Trevor, et al.. "Turning Oscillations Into Opportunities: Lessons from a Bacterial Decision Gate." Scientific Reports, 3, (2013) Nature Publishing Group: http://dx.doi.org/10.1038/srep01668.

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