Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area

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dc.citation.firstpage322en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitlePNASen_US
dc.citation.lastpage327en_US
dc.citation.volumeNumber106en_US
dc.contributor.authorSchnur, Tatiana T.en_US
dc.contributor.authorSchwartz, Myrna F.en_US
dc.contributor.authorKimberg, Daniel Y.en_US
dc.contributor.authorHirshorn, Elizabethen_US
dc.contributor.authorCoslett, H. Branchen_US
dc.contributor.authorThompson-Schill, Sharon L.en_US
dc.date.accessioned2013-05-09T19:52:41Z
dc.date.available2013-05-09T19:52:41Z
dc.date.issued2009en_US
dc.description.abstractIn order to produce a word, the intended word must be selected from a competing set of other words. In other domains where competition affects the selection process, the left inferior frontal gyrus (LIFG) responds to competition among incompatible representations. The aim of this study was to test whether the LIFG is necessary for resolution of competition in word production. Using a novel methodological approach applying the same rigorous analytic methods to neuropsychological data as is done with neuroimaging data, we compared brain activation patterns in normal speakers (using fMRI) with the results of lesion-deficit correlations in aphasic speakers who performed the same word production task designed to elicit competition during lexical selection. The degree of activation of the LIFG in normal speakers and damage to the LIFG in aphasic speakers was associated with performance on the production task. These convergent findings provide strong support for the hypothesis that the region of cortex commonly known as Broca's area (i.e., the posterior LIFG) serves to bias competitive interactions during language production.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationSchnur, Tatiana T., Schwartz, Myrna F., Kimberg, Daniel Y., et al.. "Localizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Area." <i>PNAS,</i> 106, no. 1 (2009) National Academy of Science: 322-327. http://dx.doi.org/10.1073/pnas.0805874106.
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.0805874106en_US
dc.identifier.urihttps://hdl.handle.net/1911/71109
dc.language.isoengen_US
dc.publisherNational Academy of Science
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the National Academy of Science.en_US
dc.subject.keywordaphasiaen_US
dc.subject.keywordlanguage productionen_US
dc.subject.keywordleft inferior frontal gyrusen_US
dc.subject.keywordlexical competitionen_US
dc.titleLocalizing Interference during Naming: Convergent Neuroimaging and Neuropsychological Evidence for the Function of Broca's Areaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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