Tunable calcium phosphate cement formulations for predictable local release of doxycycline

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dc.citation.articleNumber101769en_US
dc.citation.journalTitleMaterialiaen_US
dc.citation.volumeNumber28en_US
dc.contributor.authorLiu, Qianen_US
dc.contributor.authorLodoso-Torrecilla, Ireneen_US
dc.contributor.authorGunnewiek, Raquel Kleinen_US
dc.contributor.authorHarhangi, Harry R.en_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorvan Niftrik, Lauraen_US
dc.contributor.authorJansen, John A.en_US
dc.contributor.authorChen, Lilien_US
dc.contributor.authorBeucken, Jeroen J.J.P. van denen_US
dc.date.accessioned2023-05-02T14:43:12Zen_US
dc.date.available2023-05-02T14:43:12Zen_US
dc.date.issued2023en_US
dc.description.abstractBackground Osteomyelitis is a bacterial infection, which leads to bone loss. Local treatment focuses on elimination of bacteria, which is preferable for simultaneous management of the bone defect after sequestrectomy and bone reconstruction in one-stage treatment of osteomyelitis. Calcium phosphate cements (CPCs) have attracted increased attention as bone substitute material because of their injectability and in situ self-setting properties, which allow for minimally invasive surgical procedures and local drug delivery. Methods We herein established a system to achieve different release profiles of the antibiotic drug doxycycline from CPC by finetuning their formulation. These CPC formulations were generated via facile addition of hydrolytically degrading PLGA particles, varying doses of doxycycline, and addition of the lubricant CMC. Results The CPC formulations exhibited appropriate handling properties in terms of injectability and setting time. Furthermore, doxycycline release profiles showed an adequate burst release followed by a cumulative release of up to 100% over a period of 8 weeks. Importantly, the released doxycycline retained its antibacterial activity against Staphylococcus aureus, the major pathogen causing osteomyelitis. Using an in vivo implantation model, antibacterial efficacy was demonstrated by a rapid decrease of inoculated S. aureus at the CPC surface and within surrounding tissues. Conclusions Our data show the versatility of the CPC system toward local antibacterial therapy, extending its application beyond bone substitution.en_US
dc.identifier.citationLiu, Qian, Lodoso-Torrecilla, Irene, Gunnewiek, Raquel Klein, et al.. "Tunable calcium phosphate cement formulations for predictable local release of doxycycline." <i>Materialia,</i> 28, (2023) Elsevier: https://doi.org/10.1016/j.mtla.2023.101769.en_US
dc.identifier.digital1-s2-0-S2589152923000960-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.mtla.2023.101769en_US
dc.identifier.urihttps://hdl.handle.net/1911/114858en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/).en_US
dc.titleTunable calcium phosphate cement formulations for predictable local release of doxycyclineen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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