Tunable calcium phosphate cement formulations for predictable local release of doxycycline

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dc.citation.articleNumber101769
dc.citation.journalTitleMaterialia
dc.citation.volumeNumber28
dc.contributor.authorLiu, Qian
dc.contributor.authorLodoso-Torrecilla, Irene
dc.contributor.authorGunnewiek, Raquel Klein
dc.contributor.authorHarhangi, Harry R.
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorvan Niftrik, Laura
dc.contributor.authorJansen, John A.
dc.contributor.authorChen, Lili
dc.contributor.authorBeucken, Jeroen J.J.P. van den
dc.date.accessioned2023-05-02T14:43:12Z
dc.date.available2023-05-02T14:43:12Z
dc.date.issued2023
dc.description.abstractBackground Osteomyelitis is a bacterial infection, which leads to bone loss. Local treatment focuses on elimination of bacteria, which is preferable for simultaneous management of the bone defect after sequestrectomy and bone reconstruction in one-stage treatment of osteomyelitis. Calcium phosphate cements (CPCs) have attracted increased attention as bone substitute material because of their injectability and in situ self-setting properties, which allow for minimally invasive surgical procedures and local drug delivery. Methods We herein established a system to achieve different release profiles of the antibiotic drug doxycycline from CPC by finetuning their formulation. These CPC formulations were generated via facile addition of hydrolytically degrading PLGA particles, varying doses of doxycycline, and addition of the lubricant CMC. Results The CPC formulations exhibited appropriate handling properties in terms of injectability and setting time. Furthermore, doxycycline release profiles showed an adequate burst release followed by a cumulative release of up to 100% over a period of 8 weeks. Importantly, the released doxycycline retained its antibacterial activity against Staphylococcus aureus, the major pathogen causing osteomyelitis. Using an in vivo implantation model, antibacterial efficacy was demonstrated by a rapid decrease of inoculated S. aureus at the CPC surface and within surrounding tissues. Conclusions Our data show the versatility of the CPC system toward local antibacterial therapy, extending its application beyond bone substitution.
dc.identifier.citationLiu, Qian, Lodoso-Torrecilla, Irene, Gunnewiek, Raquel Klein, et al.. "Tunable calcium phosphate cement formulations for predictable local release of doxycycline." <i>Materialia,</i> 28, (2023) Elsevier: https://doi.org/10.1016/j.mtla.2023.101769.
dc.identifier.digital1-s2-0-S2589152923000960-main
dc.identifier.doihttps://doi.org/10.1016/j.mtla.2023.101769
dc.identifier.urihttps://hdl.handle.net/1911/114858
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/).
dc.titleTunable calcium phosphate cement formulations for predictable local release of doxycycline
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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