Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season
| dc.citation.firstpage | 309 | en_US |
| dc.citation.issueNumber | 8 | en_US |
| dc.citation.journalTitle | Protein Engineering, Design and Selection | en_US |
| dc.citation.lastpage | 315 | en_US |
| dc.citation.volumeNumber | 29 | en_US |
| dc.contributor.author | Li, Xi | en_US |
| dc.contributor.author | Deem, Michael W. | en_US |
| dc.date.accessioned | 2017-08-21T14:34:16Z | en_US |
| dc.date.available | 2017-08-21T14:34:16Z | en_US |
| dc.date.issued | 2016 | en_US |
| dc.description.abstract | Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable effectiveness. In this article, we discuss the use of the pepitope method to predict the dominant influenza strain and the expected vaccine effectiveness in the coming flu season. We illustrate how the effectiveness of the 2014/2015 A/Texas/50/2012 [clade 3C.1] vaccine against the A/California/02/2014 [clade 3C.3a] strain that emerged in the population can be estimated via pepitope. In addition, we show by a multidimensional scaling analysis of data collected through 2014, the emergence of a new A/New Mexico/11/2014-like cluster [clade 3C.2a] that is immunologically distinct from the A/California/02/2014-like strains. | en_US |
| dc.identifier.citation | Li, Xi and Deem, Michael W.. "Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season." <i>Protein Engineering, Design and Selection,</i> 29, no. 8 (2016) Oxford University Press: 309-315. https://doi.org/10.1093/protein/gzw017. | en_US |
| dc.identifier.digital | Influenza_evolution_H3N2_vaccine_effectiveness | en_US |
| dc.identifier.doi | https://doi.org/10.1093/protein/gzw017 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/97375 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Oxford University Press | en_US |
| dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.subject.keyword | dominant strains | en_US |
| dc.subject.keyword | influenza evolution | en_US |
| dc.subject.keyword | pepitope | en_US |
| dc.subject.keyword | phylogeny | en_US |
| dc.subject.keyword | vaccine effectiveness | en_US |
| dc.title | Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | publisher version | en_US |
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