Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis

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dc.citation.articleNumber100099en_US
dc.citation.journalTitleComprehensive Psychoneuroendocrinologyen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorWalker, Julie G.en_US
dc.contributor.authorArmstrong, Terri S.en_US
dc.contributor.authorO'Brien, Barbara J.en_US
dc.contributor.authorGilbert, Mark R.en_US
dc.contributor.authorCasarez, Rebecca L.en_US
dc.contributor.authorFagundes, Christopheren_US
dc.contributor.authorHeijnen, Cobi J.en_US
dc.contributor.authorAndersen, Clark R.en_US
dc.contributor.authorYuan, Yingen_US
dc.contributor.authorWu, Jiminen_US
dc.contributor.authorLoBiondo-Wood, Gerien_US
dc.date.accessioned2022-09-29T15:06:22Zen_US
dc.date.available2022-09-29T15:06:22Zen_US
dc.date.issued2021en_US
dc.description.abstractBackground Leptomeningeal metastasis (LM) creates symptoms related to both the disease within the nervous system and treatment toxicities. Biologic processes, such as inflammation and behavioral processes, such as the meaning ascribed to illness (Meaning of Illness: MoI), can impact physical and psychosocial symptoms. The aim of this study was to understand the relationships among MoI, physical and psychosocial symptoms, and inflammation in patients with LM. Methods Thirty enrolled participants completed the MD Anderson Symptom Inventory-Brain Tumor with spine experimental symptoms added. Meaning of illness, quality of life (QoL), and depression were captured by validated instruments. Interleukin (IL)-6 and tumor necrosis factor (TNF)-α in serum and cerebrospinal fluid (CSF) were measured by ELISA. Correlations were performed to assess relationships among the variables. Results Participants were primarily white (73%), female (63%). Median age was 54 years (34–83). Breast (50%) and lung (20%) were most common diagnosis. Higher MoI scores were associated with better QoL (p < .01) and fewer depressive symptoms (p < .01). All CSF samples contained IL-6 and all but one sample had elevated IL-6. Higher levels of IL-6 in the CSF were associated with greater symptom burden (p < .01) and interference of symptoms in daily life (p = .02) but not MoI. Conclusions MoI was associated with QoL and depression. High levels of IL-6 in the CSF were associated with more severe symptoms. This study provides the groundwork for future research, including interventional studies to improve QoL in patients with LM.en_US
dc.identifier.citationWalker, Julie G., Armstrong, Terri S., O'Brien, Barbara J., et al.. "Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis." <i>Comprehensive Psychoneuroendocrinology,</i> 8, (2021) Elsevier: https://doi.org/10.1016/j.cpnec.2021.100099.en_US
dc.identifier.digital1-s2-0-S2666497621000734-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.cpnec.2021.100099en_US
dc.identifier.urihttps://hdl.handle.net/1911/113423en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND IGO licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/igo/en_US
dc.titleAssociations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasisen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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