Periodic Migration in a Physical Model of Cells on Micropatterns

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dc.citation.firstpage158102en_US
dc.citation.issueNumber15en_US
dc.citation.journalTitlePhysical Review Lettersen_US
dc.citation.volumeNumber111en_US
dc.contributor.authorCamley, Brian A.en_US
dc.contributor.authorZhao, Yanxiangen_US
dc.contributor.authorLi, Boen_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.authorRappel, Wouter-Janen_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2016-02-05T18:38:33Zen_US
dc.date.available2016-02-05T18:38:33Zen_US
dc.date.issued2013en_US
dc.description.abstractWe extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by actin and myosin. We propose that protrusive stresses are only generated where the cell adheres, leading to the cellﾒs effective confinement to the pattern. Consistent with experimental results, simulated cells exhibit a broad range of behaviors, including steady motion, turning, bipedal motion, and periodic migration, in which the cell crawls persistently in one direction before reversing periodically. We show that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.en_US
dc.identifier.citationCamley, Brian A., Zhao, Yanxiang, Li, Bo, et al.. "Periodic Migration in a Physical Model of Cells on Micropatterns." <i>Physical Review Letters,</i> 111, no. 15 (2013) American Physical Society: 158102. http://dx.doi.org/10.1103/PhysRevLett.111.158102.en_US
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevLett.111.158102en_US
dc.identifier.urihttps://hdl.handle.net/1911/88400en_US
dc.language.isoengen_US
dc.publisherAmerican Physical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titlePeriodic Migration in a Physical Model of Cells on Micropatternsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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