Highly Angiogenic Peptide Nanofibers

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dc.citation.firstpage860
dc.citation.issueNumber1
dc.citation.journalTitleACS Nano
dc.citation.lastpage868
dc.citation.volumeNumber9
dc.contributor.authorKumar, Vivek A.
dc.contributor.authorTaylor, Nichole L.
dc.contributor.authorShi, Siyu
dc.contributor.authorWang, Benjamin K.
dc.contributor.authorJalan, Abhishek A.
dc.contributor.authorKang, Marci K.
dc.contributor.authorWickremasinghe, Navindee C.
dc.contributor.authorHartgerink, Jeffrey D.
dc.date.accessioned2017-06-14T18:46:24Z
dc.date.available2017-06-14T18:46:24Z
dc.date.issued2015
dc.description.abstractMajor limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation byproducts. Specifically, for scaffolds larger than 200–500 μm, implants must be accompanied by host angiogenesis in order to provide adequate nutrient/waste exchange in the newly forming tissue. In the current work, we design a peptide-based self-assembling nanofibrous hydrogel containing cell-mediated degradation and proangiogenic moieties that specifically address these challenges. This hydrogel can be easily delivered by syringe, is rapidly infiltrated by cells of hematopoietic and mesenchymal origin, and rapidly forms an extremely robust mature vascular network. Scaffolds show no signs of fibrous encapsulation and after 3 weeks are resorbed into the native tissue. These supramolecular assemblies may prove a vital paradigm for tissue regeneration and specifically for ischemic tissue disease.
dc.identifier.citationKumar, Vivek A., Taylor, Nichole L., Shi, Siyu, et al.. "Highly Angiogenic Peptide Nanofibers." <i>ACS Nano,</i> 9, no. 1 (2015) American Chemical Society: 860-868. https://doi.org/10.1021/nn506544b.
dc.identifier.doihttps://doi.org/10.1021/nn506544b
dc.identifier.urihttps://hdl.handle.net/1911/94846
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.subject.keywordangiogenesis
dc.subject.keywordmultidomain peptide
dc.subject.keywordself-assembly
dc.subject.keywordsupramolecular chemistry
dc.titleHighly Angiogenic Peptide Nanofibers
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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