Highly Angiogenic Peptide Nanofibers

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dc.citation.firstpage860en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage868en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorKumar, Vivek A.en_US
dc.contributor.authorTaylor, Nichole L.en_US
dc.contributor.authorShi, Siyuen_US
dc.contributor.authorWang, Benjamin K.en_US
dc.contributor.authorJalan, Abhishek A.en_US
dc.contributor.authorKang, Marci K.en_US
dc.contributor.authorWickremasinghe, Navindee C.en_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.date.accessioned2017-06-14T18:46:24Zen_US
dc.date.available2017-06-14T18:46:24Zen_US
dc.date.issued2015en_US
dc.description.abstractMajor limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation byproducts. Specifically, for scaffolds larger than 200–500 μm, implants must be accompanied by host angiogenesis in order to provide adequate nutrient/waste exchange in the newly forming tissue. In the current work, we design a peptide-based self-assembling nanofibrous hydrogel containing cell-mediated degradation and proangiogenic moieties that specifically address these challenges. This hydrogel can be easily delivered by syringe, is rapidly infiltrated by cells of hematopoietic and mesenchymal origin, and rapidly forms an extremely robust mature vascular network. Scaffolds show no signs of fibrous encapsulation and after 3 weeks are resorbed into the native tissue. These supramolecular assemblies may prove a vital paradigm for tissue regeneration and specifically for ischemic tissue disease.en_US
dc.identifier.citationKumar, Vivek A., Taylor, Nichole L., Shi, Siyu, et al.. "Highly Angiogenic Peptide Nanofibers." <i>ACS Nano,</i> 9, no. 1 (2015) American Chemical Society: 860-868. https://doi.org/10.1021/nn506544b.en_US
dc.identifier.doihttps://doi.org/10.1021/nn506544ben_US
dc.identifier.urihttps://hdl.handle.net/1911/94846en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordangiogenesisen_US
dc.subject.keywordmultidomain peptideen_US
dc.subject.keywordself-assemblyen_US
dc.subject.keywordsupramolecular chemistryen_US
dc.titleHighly Angiogenic Peptide Nanofibersen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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