Directing Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid, Semiflexible, and Flexible Chains

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dc.citation.firstpage9045en_US
dc.citation.issueNumber30en_US
dc.citation.journalTitleLangmuiren_US
dc.citation.lastpage9052en_US
dc.citation.volumeNumber30en_US
dc.contributor.authorByrom, Julieen_US
dc.contributor.authorHan, Patricen_US
dc.contributor.authorSavory, Michaelen_US
dc.contributor.authorBiswal, Sibani Lisaen_US
dc.date.accessioned2014-08-14T16:31:43Zen_US
dc.date.available2014-08-14T16:31:43Zen_US
dc.date.issued2014en_US
dc.description.abstractWe report the formation of colloidal macromolecules consisting of chains of micron-sized paramagnetic particles assembled using a magnetic field and linked with DNA. The interparticle spacing and chain flexibility were controlled by varying the magnetic field strength and the linker spring constant. Variations in the DNA lengths allowed for the generation of chains with an improved range of flexibility as compared to previous studies. These chains adopted the rigid-rod, semiflexible, and flexible conformations that are characteristic of linear polymer systems. These assembly techniques were investigated to determine the effects of the nanoscale DNA linker properties on the properties of the microscale colloidal chains. With stiff DNA linkers (564 base pairs) the chains were only stable at moderate to high field strengths and produced rigid chains. For flexible DNA linkers (8000 base pairs), high magnetic field strengths caused the linkers to be excluded from the gap between the particles, leading to a transition from very flexible chains at low field strengths to semiflexible chains at high field strengths. In the intermediate range of linker sizes, the chains exhibited predictable behavior, demonstrating increased flexibility with longer DNA linker length or smaller linking field strengths. This study provides insight into the process of directed assembly using magnetic fields and DNA by precisely tuning the components to generate colloidal analogues of linear macromolecular chains.en_US
dc.identifier.citationByrom, Julie, Han, Patric, Savory, Michael, et al.. "Directing Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid, Semiflexible, and Flexible Chains." <i>Langmuir,</i> 30, no. 30 (2014) American Chemical Society: 9045-9052. http://dx.doi.org/10.1021/la5009939.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/la5009939en_US
dc.identifier.urihttps://hdl.handle.net/1911/76515en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.titleDirecting Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid, Semiflexible, and Flexible Chainsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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