Elucidating the correlations between cancer initiation times and lifetime cancer risks
| dc.citation.articleNumber | 18940 | en_US |
| dc.citation.journalTitle | Scientific Reports | en_US |
| dc.citation.volumeNumber | 9 | en_US |
| dc.contributor.author | Teimouri, Hamid | en_US |
| dc.contributor.author | Kochugaeva, Maria P. | en_US |
| dc.contributor.author | Kolomeisky, Anatoly B. | en_US |
| dc.date.accessioned | 2020-02-14T16:39:58Z | en_US |
| dc.date.available | 2020-02-14T16:39:58Z | en_US |
| dc.date.issued | 2019 | en_US |
| dc.description.abstract | Cancer is a genetic disease that results from accumulation of unfavorable mutations. As soon as genetic and epigenetic modifications associated with these mutations become strong enough, the uncontrolled tumor cell growth is initiated, eventually spreading through healthy tissues. Clarifying the dynamics of cancer initiation is thus critically important for understanding the molecular mechanisms of tumorigenesis. Here we present a new theoretical method to evaluate the dynamic processes associated with the cancer initiation. It is based on a discrete-state stochastic description of the formation of tumors as a fixation of cancerous mutations in tissues. Using a first-passage analysis the probabilities for the cancer to appear and the times before it happens, which are viewed as fixation probabilities and fixation times, respectively, are explicitly calculated. It is predicted that the slowest cancer initiation dynamics is observed for neutral mutations, while it is fast for both advantageous and, surprisingly, disadvantageous mutations. The method is applied for estimating the cancer initiation times from experimentally available lifetime cancer risks for different types of cancer. It is found that the higher probability of the cancer to occur does not necessary lead to the faster times of starting the cancer. Our theoretical analysis helps to clarify microscopic aspects of cancer initiation processes. | en_US |
| dc.identifier.citation | Teimouri, Hamid, Kochugaeva, Maria P. and Kolomeisky, Anatoly B.. "Elucidating the correlations between cancer initiation times and lifetime cancer risks." <i>Scientific Reports,</i> 9, (2019) Springer Nature: https://doi.org/10.1038/s41598-019-55300-w. | en_US |
| dc.identifier.digital | s41598-019-55300-w | en_US |
| dc.identifier.doi | https://doi.org/10.1038/s41598-019-55300-w | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/108063 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Springer Nature | en_US |
| dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.title | Elucidating the correlations between cancer initiation times and lifetime cancer risks | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | publisher version | en_US |
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