Background The current study examined sociosexual attitudes and desires as mediators of the relationship between trait depression and sexual risk behaviors (SRB). Method Iranian Americans (n = 152) were recruited and path analyses tested a serial mediation model including the direct and indirect effects of trait depression levels on SRB. Results Trait depression had a significant, indirect effect on SRB through sociosexual attitudes and desires scores, with an indirect effect estimate -.02, SE = 0.01, 95% CI [-0.05, -0.04]. Limitations Study limitations included the use of self-report measures and the lack of longitudinal data. Conclusions Increased levels of trait depression were associated with more unrestricted sociosexual attitudes and desires which, in turn, led to greater levels of sexual risk behaviors. The study findings can serve to inform sexual health interventions for Iranian American adults.