Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm

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2016
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International Union of Crystallography
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An iterative transform method proposed previously for direct phasing of high-solvent-content protein crystals is employed for enhancing the molecular-replacement (MR) algorithm in protein crystallography. Target structures that are resistant to conventional MR due to insufficient similarity between the template and target structures might be tractable with this modified phasing method. Trial calculations involving three different structures are described to test and illustrate the methodology. The relationship of the approach toᅠPHENIX Phaser-MRᅠandᅠMR-Rosettaᅠis discussed.

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He, Hongxing, Fang, Hengrui, Miller, Mitchell D., et al.. "Improving the efficiency of molecular replacement by utilizing a new iterative transform phasing algorithm." Acta Crystallographica, A72, (2016) International Union of Crystallography: 539-547. http://dx.doi.org/10.1107/S2053273316010731.

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