A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI

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dc.citation.articleNumber2853736en_US
dc.citation.journalTitleContrast Media & Molecular Imagingen_US
dc.citation.volumeNumber2018en_US
dc.contributor.authorMoghaddam, Sakineh E.en_US
dc.contributor.authorHernández-Rivera, Mayraen_US
dc.contributor.authorZaibaq, Nicholas G.en_US
dc.contributor.authorAjala, Afisen_US
dc.contributor.authorCabreira-Hansen, Maria da Graçaen_US
dc.contributor.authorMowlazadeh-Haghighi, Sagharen_US
dc.contributor.authorWillerson, James T.en_US
dc.contributor.authorPerin, Emerson C.en_US
dc.contributor.authorMuthupillai, Rajaen_US
dc.contributor.authorWilson, Lon J.en_US
dc.date.accessioned2018-11-01T14:28:09Zen_US
dc.date.available2018-11-01T14:28:09Zen_US
dc.date.issued2018en_US
dc.description.abstractA gentle, rapid method has been developed to introduce a polyacrylic acid (PAA) polymer coating on the surface of gadonanotubes (GNTs) which significantly increases their dispersibility in water without the need of a surfactant. As a result, the polymer, with its many carboxylic acid groups, coats the surface of the GNTs to form a new GNT-polymer hybrid material (PAA-GNT) which can be highly dispersed in water (ca. 20 mg·mL−1) at physiological pH. When dispersed in water, the new PAA-GNT material is a powerful MRI contrast agent with an extremely short water proton spin-lattice relaxation time (T1) which results in a T1-weighted relaxivity of 150 mM−1·s−1 per Gd3+ ion at 1.5 T. Furthermore, the PAA-GNTs have been used to safely label porcine bone-marrow-derived mesenchymal stem cells for magnetic resonance imaging. The labeled cells display excellent image contrast in phantom imaging experiments, and transmission electron microscopy images of the labeled cells reveal the presence of highly dispersed PAA-GNTs within the cytoplasm with 1014 Gd3+ ions per cell.en_US
dc.identifier.citationMoghaddam, Sakineh E., Hernández-Rivera, Mayra, Zaibaq, Nicholas G., et al.. "A New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRI." <i>Contrast Media & Molecular Imaging,</i> 2018, (2018) Hindawi: https://doi.org/10.1155/2018/2853736.en_US
dc.identifier.digitalGadonanotube-Polymeren_US
dc.identifier.doihttps://doi.org/10.1155/2018/2853736en_US
dc.identifier.urihttps://hdl.handle.net/1911/103262en_US
dc.language.isoengen_US
dc.publisherHindawien_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA New High-Performance Gadonanotube-Polymer Hybrid Material for Stem Cell Labeling and Tracking by MRIen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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