Several nearby protoplanetary disks have been observed to display large-scale crescents in the (sub)millimeter dust continuum emission. One interpretation is that these structures correspond to anticyclonic vortices generated by the Rossby wave instability within the gaseous disk. Such vortices have local gas overdensities and are expected to concentrate dust particles with a Stokes number around unity. This process might catalyze the formation of planetesimals. Whereas recent observations showed that dust crescents are indeed regions where millimeter-size particles have abnormally high concentration relative to the gas and smaller grains, no observations have yet shown that the gas within the crescent region counterrotates with respect to the protoplanetary disk. Here we investigate the detectability of anticyclonic features through measurement of the line-of-sight component of the gas velocity obtained with ALMA. We carry out 2D hydrodynamic simulations and 3D radiative transfer calculations of a protoplanetary disk characterized by a vortex created by the tidal interaction with a massive planet. As a case study, the disk parameters are chosen to mimic the IRS 48 system, which has the most prominent crescent observed to date. We generate synthetic ALMA observations of both the dust continuum and 12CO emission around the frequency of 345 GHz. We find that the anticyclonic features of the vortex are weak but can be detected if both the source and the observational setup are properly chosen. We provide a recipe for maximizing the probability of detecting such vortex features and present an analysis procedure to infer their kinematic properties.