Encapsulation of α-Particle–Emitting225Ac3+ Ions Within Carbon Nanotubes

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dc.citation.firstpage897en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleThe Journal of Nuclear Medicineen_US
dc.citation.lastpage900en_US
dc.citation.volumeNumber56en_US
dc.contributor.authorMatson, Michael L.en_US
dc.contributor.authorVilla, Carlos H.en_US
dc.contributor.authorAnanta, Jeyarama S.en_US
dc.contributor.authorLaw, Justin J.en_US
dc.contributor.authorScheinberg, David A.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-06-22T17:41:38Zen_US
dc.date.available2016-06-22T17:41:38Zen_US
dc.date.issued2015en_US
dc.description.abstract225Ac3+ is a generator of α-particle–emitting radionuclides with 4 net α-particle decays that can be used therapeutically. Targeting 225Ac3+ by use of ligands conjugated to traditional bifunctional chelates limits the amount of 225Ac3+ that can be delivered. Ultrashort, single-walled carbon nanotubes (US-tubes), previously demonstrated as sequestering agents of trivalent lanthanide ions and small molecules, also successfully incorporate 225Ac3+. Methods: Aqueous loading of both 225Ac3+ ions and Gd3+ ions via bath sonication was used to construct 225Ac@gadonanotubes (225Ac@GNTs). The 225Ac@GNTs were subsequently challenged with heat, time, and human serum. Results: US-tubes internally loaded with both 225Ac3+ ions and Gd3+ ions show 2 distinct populations of 225Ac3+ ions: one rapidly lost in human serum and one that remains bound to the US-tubes despite additional challenge with heat, time, and serum. The presence of the latter population depended on cosequestration of Gd3+ and 225Ac3+ ions. Conclusion: US-tubes successfully sequester 225Ac3+ ions in the presence of Gd3+ ions and retain them after a human serum challenge, rendering 225Ac@GNTs candidates for radioimmunotherapy for delivery of 225Ac3+ ions at higher concentrations than is currently possible for traditional ligand carriers.en_US
dc.identifier.citationMatson, Michael L., Villa, Carlos H., Ananta, Jeyarama S., et al.. "Encapsulation of α-Particle–Emitting225Ac3+ Ions Within Carbon Nanotubes." <i>The Journal of Nuclear Medicine,</i> 56, no. 6 (2015) Society of Nuclear Medicine and Molecular Imaging: 897-900. http://dx.doi.org/10.2967/jnumed.115.158311.en_US
dc.identifier.doihttp://dx.doi.org/10.2967/jnumed.115.158311en_US
dc.identifier.urihttps://hdl.handle.net/1911/90523en_US
dc.language.isoengen_US
dc.publisherSociety of Nuclear Medicine and Molecular Imagingen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Society of Nuclear Medicine and Molecular Imaging.en_US
dc.subject.keyword225Acen_US
dc.subject.keywordcarbon nanotubeen_US
dc.subject.keywordalpha therapyen_US
dc.subject.keywordnanotechnologyen_US
dc.titleEncapsulation of α-Particle–Emitting225Ac3+ Ions Within Carbon Nanotubesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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