Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms

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dc.citation.articleNumber107824
dc.citation.journalTitleNeurobiology of Learning and Memory
dc.citation.volumeNumber205
dc.contributor.authorHayes, Brandon K.
dc.contributor.authorHarikumar, Amritha
dc.contributor.authorFerguson, Lorena A.
dc.contributor.authorDicker, Eva E.
dc.contributor.authorDenny, Bryan T.
dc.contributor.authorLeal, Stephanie L.
dc.date.accessioned2024-05-08T18:56:09Z
dc.date.available2024-05-08T18:56:09Z
dc.date.issued2023
dc.description.abstractIndividuals with depression exhibit dysfunctional emotion regulation, general episodic memory deficits, and a negativity bias, where negative experiences are better remembered. Recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation – a computation that processes experiences with overlapping features as unique. Previously, we found that individuals with depressive symptoms show enhanced negative and impaired neutral mnemonic discrimination. The current study aimed to investigate emotion regulation as an approach toward modifying memory encoding of negative and neutral events in individuals with depressive symptoms. Here we show that applying psychological distancing (a cognitive reappraisal strategy characterized by taking a third-person perspective toward negative events) during encoding was associated with reduced negative and enhanced neutral mnemonic discrimination during retrieval in individuals with depressive symptoms. These results suggest that applying emotion regulation techniques during encoding may provide an effective approach toward altering dysfunctional memory in those with depressive symptoms. Given that pharmacological treatments often fail to treat depression, emotion regulation provides a powerful and practical approach toward modifying cognitive and emotional processes. Future neuroimaging studies will be important to determine how emotion regulation impacts the neural mechanisms underlying these findings.
dc.identifier.citationHayes, B. K., Harikumar, A., Ferguson, L. A., Dicker, E. E., Denny, B. T., & Leal, S. L. (2023). Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms. Neurobiology of Learning and Memory, 205, 107824. https://doi.org/10.1016/j.nlm.2023.107824
dc.identifier.digital1-s20-S1074742723001053-main
dc.identifier.doihttps://doi.org/10.1016/j.nlm.2023.107824
dc.identifier.urihttps://hdl.handle.net/1911/115654
dc.language.isoeng
dc.publisherElsevier
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleEmotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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