Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms

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dc.citation.articleNumber107824en_US
dc.citation.journalTitleNeurobiology of Learning and Memoryen_US
dc.citation.volumeNumber205en_US
dc.contributor.authorHayes, Brandon K.en_US
dc.contributor.authorHarikumar, Amrithaen_US
dc.contributor.authorFerguson, Lorena A.en_US
dc.contributor.authorDicker, Eva E.en_US
dc.contributor.authorDenny, Bryan T.en_US
dc.contributor.authorLeal, Stephanie L.en_US
dc.date.accessioned2024-05-08T18:56:09Zen_US
dc.date.available2024-05-08T18:56:09Zen_US
dc.date.issued2023en_US
dc.description.abstractIndividuals with depression exhibit dysfunctional emotion regulation, general episodic memory deficits, and a negativity bias, where negative experiences are better remembered. Recent work suggests that the negativity bias in depression may be driven by enhanced mnemonic discrimination, a memory measure that relies on hippocampal pattern separation – a computation that processes experiences with overlapping features as unique. Previously, we found that individuals with depressive symptoms show enhanced negative and impaired neutral mnemonic discrimination. The current study aimed to investigate emotion regulation as an approach toward modifying memory encoding of negative and neutral events in individuals with depressive symptoms. Here we show that applying psychological distancing (a cognitive reappraisal strategy characterized by taking a third-person perspective toward negative events) during encoding was associated with reduced negative and enhanced neutral mnemonic discrimination during retrieval in individuals with depressive symptoms. These results suggest that applying emotion regulation techniques during encoding may provide an effective approach toward altering dysfunctional memory in those with depressive symptoms. Given that pharmacological treatments often fail to treat depression, emotion regulation provides a powerful and practical approach toward modifying cognitive and emotional processes. Future neuroimaging studies will be important to determine how emotion regulation impacts the neural mechanisms underlying these findings.en_US
dc.identifier.citationHayes, B. K., Harikumar, A., Ferguson, L. A., Dicker, E. E., Denny, B. T., & Leal, S. L. (2023). Emotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptoms. Neurobiology of Learning and Memory, 205, 107824. https://doi.org/10.1016/j.nlm.2023.107824en_US
dc.identifier.digital1-s20-S1074742723001053-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.nlm.2023.107824en_US
dc.identifier.urihttps://hdl.handle.net/1911/115654en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleEmotion regulation during encoding reduces negative and enhances neutral mnemonic discrimination in individuals with depressive symptomsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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