Self-organized stress patterns drive state transitions in actin cortices

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dc.citation.articleNumbereaar2847en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorTan, Tzer Hanen_US
dc.contributor.authorMalik-Garbi, Mayaen_US
dc.contributor.authorAbu-Shah, Enasen_US
dc.contributor.authorLi, Junangen_US
dc.contributor.authorSharma, Abhinaven_US
dc.contributor.authorMacKintosh, Fred C.en_US
dc.contributor.authorKeren, Kinnereten_US
dc.contributor.authorSchmidt, Christoph F.en_US
dc.contributor.authorFakhri, Niktaen_US
dc.contributor.orgCenter for Theoretical Biophysicsen_US
dc.date.accessioned2018-09-27T17:33:26Zen_US
dc.date.available2018-09-27T17:33:26Zen_US
dc.date.issued2018en_US
dc.description.abstractBiological functions rely on ordered structures and intricately controlled collective dynamics. This order in living systems is typically established and sustained by continuous dissipation of energy. The emergence of collective patterns of motion is unique to nonequilibrium systems and is a manifestation of dynamic steady states. Mechanical resilience of animal cells is largely controlled by the actomyosin cortex. The cortex provides stability but is, at the same time, highly adaptable due to rapid turnover of its components. Dynamic functions involve regulated transitions between different steady states of the cortex. We find that model actomyosin cortices, constructed to maintain turnover, self-organize into distinct nonequilibrium steady states when we vary cross-link density. The feedback between actin network structure and organization of stress-generating myosin motors defines the symmetries of the dynamic steady states. A marginally cross-linked state displays divergence-free long-range flow patterns. Higher cross-link density causes structural symmetry breaking, resulting in a stationary converging flow pattern. We track the flow patterns in the model actomyosin cortices using fluorescent single-walled carbon nanotubes as novel probes. The self-organization of stress patterns we have observed in a model system can have direct implications for biological functions.en_US
dc.identifier.citationTan, Tzer Han, Malik-Garbi, Maya, Abu-Shah, Enas, et al.. "Self-organized stress patterns drive state transitions in actin cortices." <i>Science Advances,</i> 4, no. 6 (2018) AAAS: https://doi.org/10.1126/sciadv.aar2847.en_US
dc.identifier.digitaleaar2847en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.aar2847en_US
dc.identifier.urihttps://hdl.handle.net/1911/102728en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleSelf-organized stress patterns drive state transitions in actin corticesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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