Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells

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dc.citation.journalTitleNanoscale Research Lettersen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorCorr, Stuart J.en_US
dc.contributor.authorRaoof, Mustafaen_US
dc.contributor.authorCisneros, Brandon T.en_US
dc.contributor.authorKuznetsov, Oleksandren_US
dc.contributor.authorMassey, Katherynen_US
dc.contributor.authorKaluarachchi, Warna D.en_US
dc.contributor.authorCheney, Matthew A.en_US
dc.contributor.authorBillups, Edward W.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorCurley, Steven A.en_US
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-01-29T16:52:03Zen_US
dc.date.available2016-01-29T16:52:03Zen_US
dc.date.issued2013en_US
dc.description.abstractHighly exfoliated sulfonated graphene sheets (SGSs), an alternative to graphene oxide and graphene derivatives, were synthesized, characterized, and applied to liver cancer cells in vitro. Cytotoxicity profiles were obtained using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, WST-1[2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, and lactate dehydrogenase release colorimetric assays. These particles were found to be non-toxic across the concentration range of 0.1 to 10 μg/ml. Internalization of SGSs was also studied by means of optical and electron microscopy. Although not conclusive, high-resolution transmission and scanning electron microscopy revealed variant internalization behaviors where some of the SGS became folded and compartmentalized into tight bundles within cellular organelles. The ability for liver cancer cells to internalize, fold, and compartmentalize graphene structures is a phenomenon not previously documented for graphene cell biology and should be further investigated.en_US
dc.identifier.citationCorr, Stuart J., Raoof, Mustafa, Cisneros, Brandon T., et al.. "Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells." <i>Nanoscale Research Letters,</i> 8, (2013) Springer: http://dx.doi.org/10.1186/1556-276X-8-208.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/1556-276X-8-208en_US
dc.identifier.urihttps://hdl.handle.net/1911/88255en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en_US
dc.subject.keywordcytotoxicityen_US
dc.subject.keywordsulfonated graphene sheetsen_US
dc.subject.keywordcancer cellsen_US
dc.titleCytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cellsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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