Reassessing the exon–foldon correspondence using frustration analysis

Simple item page
dc.citation.articleNumbere2400151121en_US
dc.citation.issueNumber28en_US
dc.citation.journalTitleProceedings of the National Academy of Sciencesen_US
dc.citation.volumeNumber121en_US
dc.contributor.authorGalpern, Ezequiel A.en_US
dc.contributor.authorJaafari, Hanaen_US
dc.contributor.authorBueno, Carlosen_US
dc.contributor.authorWolynes, Peter G.en_US
dc.contributor.authorFerreiro, Diego U.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2024-09-10T19:29:03Zen_US
dc.date.available2024-09-10T19:29:03Zen_US
dc.date.issued2024en_US
dc.description.abstractProtein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across a set of 38 abundant and conserved protein families. Taking advantage of genomic exon–intron organization and extensive protein sequence data, we explore exon boundary conservation and assess the foldon-like behavior of exons using energy landscape theoretic measurements. We found deviations in the exon size distribution from exponential decay indicating selection in evolution. We show that when taken together there is a pronounced tendency to independent foldability for segments corresponding to the more conserved exons, supporting the idea of exon–foldon correspondence. While 45% of the families follow this general trend when analyzed individually, there are some families for which other stronger functional determinants, such as preserving frustrated active sites, may be acting. We further develop a systematic partitioning of protein domains using exon boundary hotspots, showing that minimal common exons correspond with uninterrupted alpha and/or beta elements for the majority of the families but not for all of them.en_US
dc.identifier.citationGalpern, E. A., Jaafari, H., Bueno, C., Wolynes, P. G., & Ferreiro, D. U. (2024). Reassessing the exon–foldon correspondence using frustration analysis. Proceedings of the National Academy of Sciences, 121(28), e2400151121. https://doi.org/10.1073/pnas.2400151121en_US
dc.identifier.digitalgalpern-et-al-2024en_US
dc.identifier.doihttps://doi.org/10.1073/pnas.2400151121en_US
dc.identifier.urihttps://hdl.handle.net/1911/117863en_US
dc.language.isoengen_US
dc.publisherNational Academy of Sciencesen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleReassessing the exon–foldon correspondence using frustration analysisen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
galpern-et-al-2024.pdf
Size:
6.32 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications
Physics and Astronomy Publications