Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models

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dc.citation.articleNumber929
dc.citation.journalTitleFrontiers in Physiology
dc.citation.volumeNumber11
dc.contributor.authorBocci, Federico
dc.contributor.authorOnuchic, José Nelson
dc.contributor.authorJolly, Mohit Kumar
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2020-11-03T19:41:52Z
dc.date.available2020-11-03T19:41:52Z
dc.date.issued2020
dc.description.abstractNotch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the emergent spatiotemporal patterning in a tissue through ligand-receptor interactions among transmembrane molecules of neighboring cells, as seen in embryonic development, angiogenesis, or wound healing. Due to its ubiquitous nature, Notch signaling is also implicated in several aspects of cancer progression, including tumor angiogenesis, stemness of cancer cells and cellular invasion. Here, we review experimental and computational models that help understand the operating principles of cell patterning driven by Notch signaling. First, we discuss the basic mechanisms of spatial patterning via canonical lateral inhibition and lateral induction mechanisms, including examples from angiogenesis, inner ear development and cancer metastasis. Next, we analyze additional layers of complexity in the Notch pathway, including the effect of varying cell sizes and shapes, ligand-receptor binding within the same cell, variable binding affinity of different ligand/receptor subtypes, and filopodia. Finally, we discuss some recent evidence of mechanosensitivity in the Notch pathway in driving collective epithelial cell migration and cardiovascular morphogenesis.
dc.identifier.citationBocci, Federico, Onuchic, José Nelson and Jolly, Mohit Kumar. "Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models." <i>Frontiers in Physiology,</i> 11, (2020) Frontiers: https://doi.org/10.3389/fphys.2020.00929.
dc.identifier.doihttps://doi.org/10.3389/fphys.2020.00929
dc.identifier.urihttps://hdl.handle.net/1911/109482
dc.language.isoeng
dc.publisherFrontiers
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleUnderstanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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