Total Synthesis of Myceliothermophins C, D and E
dc.citation.firstpage | 10970 | en_US |
dc.citation.issueNumber | 41 | en_US |
dc.citation.journalTitle | Angewandte Chemie International Edition | en_US |
dc.citation.lastpage | 10974 | en_US |
dc.citation.volumeNumber | 53 | en_US |
dc.contributor.author | Nicolaou, K.C. | en_US |
dc.contributor.author | Shi, Lei | en_US |
dc.contributor.author | Lu, Min | en_US |
dc.contributor.author | Pattanayak, Manas R. | en_US |
dc.contributor.author | Shah, Akshay A. | en_US |
dc.contributor.author | Ioannidou, Heraklidia A. | en_US |
dc.contributor.author | Lamani, Manjunath | en_US |
dc.contributor.org | BioScience Research Collaborative | en_US |
dc.date.accessioned | 2015-10-29T18:23:24Z | en_US |
dc.date.available | 2015-10-29T18:23:24Z | en_US |
dc.date.issued | 2014 | en_US |
dc.description.abstract | The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms. | en_US |
dc.identifier.citation | Nicolaou, K.C., Shi, Lei, Lu, Min, et al.. "Total Synthesis of Myceliothermophins C, D and E." <i>Angewandte Chemie International Edition,</i> 53, no. 41 (2014) Wiley: 10970-10974. http://dx.doi.org/10.1002/anie.201406815. | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/anie.201406815 | en_US |
dc.identifier.uri | https://hdl.handle.net/1911/81981 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley. | en_US |
dc.subject.keyword | cascade reaction | en_US |
dc.subject.keyword | decalin | en_US |
dc.subject.keyword | natural products | en_US |
dc.subject.keyword | polyketides | en_US |
dc.subject.keyword | total synthesis | en_US |
dc.title | Total Synthesis of Myceliothermophins C, D and E | en_US |
dc.type | Journal article | en_US |
dc.type.dcmi | Text | en_US |
dc.type.publication | post-print | en_US |