Total Synthesis of Myceliothermophins C, D and E

dc.citation.firstpage10970en_US
dc.citation.issueNumber41en_US
dc.citation.journalTitleAngewandte Chemie International Editionen_US
dc.citation.lastpage10974en_US
dc.citation.volumeNumber53en_US
dc.contributor.authorNicolaou, K.C.en_US
dc.contributor.authorShi, Leien_US
dc.contributor.authorLu, Minen_US
dc.contributor.authorPattanayak, Manas R.en_US
dc.contributor.authorShah, Akshay A.en_US
dc.contributor.authorIoannidou, Heraklidia A.en_US
dc.contributor.authorLamani, Manjunathen_US
dc.contributor.orgBioScience Research Collaborativeen_US
dc.date.accessioned2015-10-29T18:23:24Zen_US
dc.date.available2015-10-29T18:23:24Zen_US
dc.date.issued2014en_US
dc.description.abstractThe total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.en_US
dc.identifier.citationNicolaou, K.C., Shi, Lei, Lu, Min, et al.. "Total Synthesis of Myceliothermophins C, D and E." <i>Angewandte Chemie International Edition,</i> 53, no. 41 (2014) Wiley: 10970-10974. http://dx.doi.org/10.1002/anie.201406815.en_US
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201406815en_US
dc.identifier.urihttps://hdl.handle.net/1911/81981en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.en_US
dc.subject.keywordcascade reactionen_US
dc.subject.keyworddecalinen_US
dc.subject.keywordnatural productsen_US
dc.subject.keywordpolyketidesen_US
dc.subject.keywordtotal synthesisen_US
dc.titleTotal Synthesis of Myceliothermophins C, D and Een_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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