Total Synthesis of Myceliothermophins C, D and E
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.
Nicolaou, K.C., Shi, Lei, Lu, Min, et al.. "Total Synthesis of Myceliothermophins C, D and E." Angewandte Chemie International Edition, 53, no. 41 (2014) Wiley: 10970-10974. http://dx.doi.org/10.1002/anie.201406815.