Tensegrity and motor-driven effective interactions in a model cytoskeleton

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dc.citation.articleNumber145102en_US
dc.citation.issueNumber14en_US
dc.citation.journalTitleThe Journal of Chemical Physicsen_US
dc.citation.volumeNumber136en_US
dc.contributor.authorWang, Shenshenen_US
dc.contributor.authorWolynes, Peter G.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2017-05-03T16:12:49Zen_US
dc.date.available2017-05-03T16:12:49Zen_US
dc.date.issued2012en_US
dc.description.abstractActomyosin networks are major structural components of the cell. They provide mechanical integrity and allow dynamic remodeling of eukaryotic cells, self-organizing into the diverse patterns essential for development. We provide a theoretical framework to investigate the intricate interplay between local force generation, network connectivity, and collective action of molecular motors. This framework is capable of accommodating both regular and heterogeneous pattern formation, arrested coarsening and macroscopic contraction in a unified manner. We model the actomyosin system as a motorized cat's cradle consisting of a crosslinked network of nonlinear elastic filaments subjected to spatially anti-correlated motor kicks acting on motorized (fibril) crosslinks. The phase diagram suggests there can be arrested phase separation which provides a natural explanation for the aggregation and coalescence of actomyosin condensates. Simulation studies confirm the theoretical picture that a nonequilibrium many-body system driven by correlated motor kicks can behave as if it were at an effective equilibrium, but with modified interactions that account for the correlation of the motor driven motions of the actively bonded nodes. Regular aster patterns are observed both in Brownian dynamics simulations at effective equilibrium and in the complete stochastic simulations. The results show that large-scale contraction requires correlated kicking.en_US
dc.identifier.citationWang, Shenshen and Wolynes, Peter G.. "Tensegrity and motor-driven effective interactions in a model cytoskeleton." <i>The Journal of Chemical Physics,</i> 136, no. 14 (2012) AIP Publishing LLC: https://doi.org/10.1063/1.3702583.en_US
dc.identifier.doihttps://doi.org/10.1063/1.3702583en_US
dc.identifier.urihttps://hdl.handle.net/1911/94123en_US
dc.language.isoengen_US
dc.publisherAIP Publishing LLCen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleTensegrity and motor-driven effective interactions in a model cytoskeletonen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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