High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration

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dc.citation.articleNumber2207698
dc.citation.issueNumber16
dc.citation.journalTitleAdvanced Science
dc.citation.volumeNumber10
dc.contributor.authorWang, Ruohan
dc.contributor.authorWang, Mingsai
dc.contributor.authorJin, Rongrong
dc.contributor.authorWang, Yanfei
dc.contributor.authorYi, Min
dc.contributor.authorLi, Qinye
dc.contributor.authorLi, Juan
dc.contributor.authorZhang, Kai
dc.contributor.authorSun, Chenghua
dc.contributor.authorNie, Yu
dc.contributor.authorHuang, Chongxiang
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorZhang, Xingdong
dc.date.accessioned2023-07-21T16:13:37Z
dc.date.available2023-07-21T16:13:37Z
dc.date.issued2023
dc.description.abstractPure titanium is widely used in clinical implants, but its bioinert properties (poor strength and mediocre effect on bone healing) limit its use under load-bearing conditions. Modeling on the structure of collagen fibrils and specific nanocrystal plane arrangement of hydroxyapatite in the natural bone, a new type of titanium (Ti) with a highly aligned fibrous-grained (FG) microstructure is constructed. The improved attributes of FG Ti include high strength (≈950 MPa), outstanding affinity to new bone growth, and tight bone-implant contact. The bone-mimicking fibrous grains induce an aligned surface topological structure conducive to forming close contact with osteoblasts and promotes the expression of osteogenic genes. Concurrently, the predominant Ti(0002) crystal plane of FG Ti induces the formation of hydrophilic anatase titanium oxide layers, which accelerate biomineralization. In conclusion, this bioinspired FG Ti not only proves to show mechanical and bone-regenerative improvements but it also provides a new strategy for the future design of metallic biomaterials.
dc.identifier.citationWang, Ruohan, Wang, Mingsai, Jin, Rongrong, et al.. "High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration." <i>Advanced Science,</i> 10, no. 16 (2023) Wiley: https://doi.org/10.1002/advs.202207698.
dc.identifier.digital2023-Wang
dc.identifier.doihttps://doi.org/10.1002/advs.202207698
dc.identifier.urihttps://hdl.handle.net/1911/114970
dc.language.isoeng
dc.publisherWiley
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHigh Strength Titanium with Fibrous Grain for Advanced Bone Regeneration
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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