High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration

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dc.citation.articleNumber2207698en_US
dc.citation.issueNumber16en_US
dc.citation.journalTitleAdvanced Scienceen_US
dc.citation.volumeNumber10en_US
dc.contributor.authorWang, Ruohanen_US
dc.contributor.authorWang, Mingsaien_US
dc.contributor.authorJin, Rongrongen_US
dc.contributor.authorWang, Yanfeien_US
dc.contributor.authorYi, Minen_US
dc.contributor.authorLi, Qinyeen_US
dc.contributor.authorLi, Juanen_US
dc.contributor.authorZhang, Kaien_US
dc.contributor.authorSun, Chenghuaen_US
dc.contributor.authorNie, Yuen_US
dc.contributor.authorHuang, Chongxiangen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorZhang, Xingdongen_US
dc.date.accessioned2023-07-21T16:13:37Zen_US
dc.date.available2023-07-21T16:13:37Zen_US
dc.date.issued2023en_US
dc.description.abstractPure titanium is widely used in clinical implants, but its bioinert properties (poor strength and mediocre effect on bone healing) limit its use under load-bearing conditions. Modeling on the structure of collagen fibrils and specific nanocrystal plane arrangement of hydroxyapatite in the natural bone, a new type of titanium (Ti) with a highly aligned fibrous-grained (FG) microstructure is constructed. The improved attributes of FG Ti include high strength (≈950 MPa), outstanding affinity to new bone growth, and tight bone-implant contact. The bone-mimicking fibrous grains induce an aligned surface topological structure conducive to forming close contact with osteoblasts and promotes the expression of osteogenic genes. Concurrently, the predominant Ti(0002) crystal plane of FG Ti induces the formation of hydrophilic anatase titanium oxide layers, which accelerate biomineralization. In conclusion, this bioinspired FG Ti not only proves to show mechanical and bone-regenerative improvements but it also provides a new strategy for the future design of metallic biomaterials.en_US
dc.identifier.citationWang, Ruohan, Wang, Mingsai, Jin, Rongrong, et al.. "High Strength Titanium with Fibrous Grain for Advanced Bone Regeneration." <i>Advanced Science,</i> 10, no. 16 (2023) Wiley: https://doi.org/10.1002/advs.202207698.en_US
dc.identifier.digital2023-Wangen_US
dc.identifier.doihttps://doi.org/10.1002/advs.202207698en_US
dc.identifier.urihttps://hdl.handle.net/1911/114970en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleHigh Strength Titanium with Fibrous Grain for Advanced Bone Regenerationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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