How input fluctuations reshape the dynamics of a biological switching system

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dc.citation.firstpage061910
dc.citation.journalTitlePhysical Review Een_US
dc.citation.volumeNumber86en_US
dc.contributor.authorHu, Bo
dc.contributor.authorKessler, David A.
dc.contributor.authorRappel, Wouter-Jan
dc.contributor.authorLevine, Herbert
dc.contributor.funderNational Science Foundationen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.contributor.publisherAmerican Physical Societyen_US
dc.date.accessioned2013-07-12T20:09:30Z
dc.date.available2013-07-12T20:09:30Z
dc.date.issued2012
dc.description.abstractAn important task in quantitative biology is to understand the role of stochasticity in biochemical regulation. Here, as an extension of our recent work [Phys. Rev. Lett. 107, 148101 (2011)], we study how input fluctuations affect the stochastic dynamics of a simple biological switch. In our model, the on transition rate of the switch is directly regulated by a noisy input signal, which is described as a non-negative mean-reverting diffusion process. This continuous process can be a good approximation of the discrete birth-death process and is much more analytically tractable.Within this setup, we apply the Feynman-Kac theorem to investigate the statistical features of the output switching dynamics. Consistent with our previous findings, the input noise is found to effectively suppress the input-dependent transitions.We show analytically that this effect becomes significant when the input signal fluctuates greatly in amplitude and reverts slowly to its mean.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationHu, Bo, Kessler, David A., Rappel, Wouter-Jan, et al.. "How input fluctuations reshape the dynamics of a biological switching system." <i>Physical Review E,</i> 86, (2012) 061910. http://dx.doi.org/10.1103/PhysRevE.86.061910.*
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.86.061910en_US
dc.identifier.grantIDPHY-0822283 (National Science Foundation)
dc.identifier.urihttps://hdl.handle.net/1911/71549
dc.language.isoengen_US
dc.titleHow input fluctuations reshape the dynamics of a biological switching systemen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
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