How input fluctuations reshape the dynamics of a biological switching system
An important task in quantitative biology is to understand the role of stochasticity in biochemical regulation. Here, as an extension of our recent work [Phys. Rev. Lett. 107, 148101 (2011)], we study how input fluctuations affect the stochastic dynamics of a simple biological switch. In our model, the on transition rate of the switch is directly regulated by a noisy input signal, which is described as a non-negative mean-reverting diffusion process. This continuous process can be a good approximation of the discrete birth-death process and is much more analytically tractable.Within this setup, we apply the Feynman-Kac theorem to investigate the statistical features of the output switching dynamics. Consistent with our previous findings, the input noise is found to effectively suppress the input-dependent transitions.We show analytically that this effect becomes significant when the input signal fluctuates greatly in amplitude and reverts slowly to its mean.
Hu, Bo, Kessler, David A., Rappel, Wouter-Jan, et al.. "How input fluctuations reshape the dynamics of a biological switching system." Physical Review E, 86, (2012) 061910. http://dx.doi.org/10.1103/PhysRevE.86.061910.