Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart

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dc.citation.firstpage9822en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleACS Nanoen_US
dc.citation.lastpage9832en_US
dc.citation.volumeNumber8en_US
dc.contributor.authorPok, Seokwonen_US
dc.contributor.authorVitale, Flaviaen_US
dc.contributor.authorEichmann, Shannon L.en_US
dc.contributor.authorBenavides, Omar M.en_US
dc.contributor.authorPasquali, Matteoen_US
dc.contributor.authorJacot, Jeffrey G.en_US
dc.contributor.orgThe Smalley Institute for Nanoscale Science & Technologyen_US
dc.date.accessioned2015-10-29T18:23:25Zen_US
dc.date.available2015-10-29T18:23:25Zen_US
dc.date.issued2014en_US
dc.description.abstractThe major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled carbon nanotubes, on the order of tens of parts per million, incorporated in a gelatin–chitosan hydrogel act as electrical nanobridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating, and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track repair for Tetralogy of Fallot, atrial and ventricular septal defect repair, and other cardiac defects, without the risk of inducing cardiac arrhythmias.en_US
dc.identifier.citationPok, Seokwon, Vitale, Flavia, Eichmann, Shannon L., et al.. "Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart." <i>ACS Nano,</i> 8, no. 10 (2014) American Chemical Society: 9822-9832. http://dx.doi.org/10.1021/nn503693h.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/nn503693hen_US
dc.identifier.urihttps://hdl.handle.net/1911/81986en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en_US
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlen_US
dc.subject.keywordcarbon nanotubesen_US
dc.subject.keywordtissue engineeringen_US
dc.subject.keywordcardiomyocytesen_US
dc.subject.keywordheart defectsen_US
dc.subject.keywordconduction velocityen_US
dc.subject.keywordaction potentialen_US
dc.titleBiocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Hearten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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