Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart

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dc.citation.firstpage9822
dc.citation.issueNumber10
dc.citation.journalTitleACS Nano
dc.citation.lastpage9832
dc.citation.volumeNumber8
dc.contributor.authorPok, Seokwon
dc.contributor.authorVitale, Flavia
dc.contributor.authorEichmann, Shannon L.
dc.contributor.authorBenavides, Omar M.
dc.contributor.authorPasquali, Matteo
dc.contributor.authorJacot, Jeffrey G.
dc.contributor.orgThe Smalley Institute for Nanoscale Science & Technology
dc.date.accessioned2015-10-29T18:23:25Z
dc.date.available2015-10-29T18:23:25Z
dc.date.issued2014
dc.description.abstractThe major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled carbon nanotubes, on the order of tens of parts per million, incorporated in a gelatin–chitosan hydrogel act as electrical nanobridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating, and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track repair for Tetralogy of Fallot, atrial and ventricular septal defect repair, and other cardiac defects, without the risk of inducing cardiac arrhythmias.
dc.identifier.citationPok, Seokwon, Vitale, Flavia, Eichmann, Shannon L., et al.. "Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart." <i>ACS Nano,</i> 8, no. 10 (2014) American Chemical Society: 9822-9832. http://dx.doi.org/10.1021/nn503693h.
dc.identifier.doihttp://dx.doi.org/10.1021/nn503693h
dc.identifier.urihttps://hdl.handle.net/1911/81986
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
dc.rights.urihttp://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.subject.keywordcarbon nanotubes
dc.subject.keywordtissue engineering
dc.subject.keywordcardiomyocytes
dc.subject.keywordheart defects
dc.subject.keywordconduction velocity
dc.subject.keywordaction potential
dc.titleBiocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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