Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report

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dc.citation.articleNumber137en_US
dc.citation.journalTitleBMC Medical Genomicsen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorChen, Yujieen_US
dc.contributor.authorTalukder, Rafeeen_US
dc.contributor.authorMerritt, Brian Y.en_US
dc.contributor.authorKing, Katherine Y.en_US
dc.contributor.authorKimmel, Mareken_US
dc.contributor.authorRivero, Gustavoen_US
dc.contributor.authorSosa, Rominaen_US
dc.date.accessioned2021-06-10T17:36:57Zen_US
dc.date.available2021-06-10T17:36:57Zen_US
dc.date.issued2021en_US
dc.description.abstractWe report a patient with Essential Thrombocythemia (ET), subsequently diagnosed with concurrent myeloid and lymphoid leukemia. Generally, the molecular mechanisms underlying leukemic transformation of Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are poorly understood. Risk of transformation to acute myelogenous leukemia (AML) is low; transformation to both AML and acute lymphoblastic leukemia (ALL) is extremely low. Genetic defects, including allele burden, order of mutation acquisition, clonal heterogeneity and epigenetic mechanisms are important contributors to disease acceleration.en_US
dc.identifier.citationChen, Yujie, Talukder, Rafee, Merritt, Brian Y., et al.. "Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report." <i>BMC Medical Genomics,</i> 14, (2021) BioMed Central: https://doi.org/10.1186/s12920-021-00986-z.en_US
dc.identifier.digitals12920-021-00986-zen_US
dc.identifier.doihttps://doi.org/10.1186/s12920-021-00986-zen_US
dc.identifier.urihttps://hdl.handle.net/1911/110723en_US
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.en_US
dc.titleGenomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case reporten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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