Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report

We report a patient with Essential Thrombocythemia (ET), subsequently diagnosed with concurrent myeloid and lymphoid leukemia. Generally, the molecular mechanisms underlying leukemic transformation of Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are poorly understood. Risk of transformation to acute myelogenous leukemia (AML) is low; transformation to both AML and acute lymphoblastic leukemia (ALL) is extremely low. Genetic defects, including allele burden, order of mutation acquisition, clonal heterogeneity and epigenetic mechanisms are important contributors to disease acceleration.

Type

Journal article

Citation

Chen, Yujie, Talukder, Rafee, Merritt, Brian Y., et al.. "Genomic trajectory in leukemogenesis of myeloproliferative neoplasms: a case report." BMC Medical Genomics, 14, (2021) BioMed Central: https://doi.org/10.1186/s12920-021-00986-z.

Published Version

https://doi.org/10.1186/s12920-021-00986-z

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