Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer

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dc.citation.articleNumber105719en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleiScienceen_US
dc.citation.volumeNumber26en_US
dc.contributor.authorGalbraith, Madelineen_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.authorOnuchic, José N.en_US
dc.contributor.authorJia, Dongyaen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2023-01-27T14:47:08Zen_US
dc.date.available2023-01-27T14:47:08Zen_US
dc.date.issued2023en_US
dc.description.abstractCancer metastasis relies on an orchestration of traits driven by different interacting functional modules, including metabolism and epithelial-mesenchymal transition (EMT). During metastasis, cancer cells can acquire a hybrid metabolic phenotype (W/O) by increasing oxidative phosphorylation without compromising glycolysis and they can acquire a hybrid epithelial/mesenchymal (E/M) phenotype by engaging EMT. Both the W/O and E/M states are associated with high metastatic potentials, and many regulatory links coupling metabolism and EMT have been identified. Here, we investigate the coupled decision-making networks of metabolism and EMT. Their crosstalk can exhibit synergistic or antagonistic effects on the acquisition and stability of different coupled metabolism-EMT states. Strikingly, the aggressive E/M-W/O state can be enabled and stabilized by the crosstalk irrespective of these hybrid states’ availability in individual metabolism or EMT modules. Our work emphasizes the mutual activation between metabolism and EMT, providing an important step toward understanding the multifaceted nature of cancer metastasis.en_US
dc.identifier.citationGalbraith, Madeline, Levine, Herbert, Onuchic, José N., et al.. "Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer." <i>iScience,</i> 26, no. 1 (2023) Cell Press: https://doi.org/10.1016/j.isci.2022.105719.en_US
dc.identifier.digital1-s2-0-S2589004222019927-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.105719en_US
dc.identifier.urihttps://hdl.handle.net/1911/114248en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.titleDecoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in canceren_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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