EMT and MET: necessary or permissive for metastasis?

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dc.citation.firstpage755
dc.citation.issueNumber7
dc.citation.journalTitleMolecular Oncology
dc.citation.lastpage769
dc.citation.volumeNumber11
dc.contributor.authorJolly, Mohit Kumar
dc.contributor.authorWare, Kathryn E.
dc.contributor.authorGilja, Shivee
dc.contributor.authorSomarelli, Jason A.
dc.contributor.authorLevine, Herbert
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2017-08-21T14:34:15Z
dc.date.available2017-08-21T14:34:15Z
dc.date.issued2017
dc.description.abstractEpithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.
dc.identifier.citationJolly, Mohit Kumar, Ware, Kathryn E., Gilja, Shivee, et al.. "EMT and MET: necessary or permissive for metastasis?." <i>Molecular Oncology,</i> 11, no. 7 (2017) Wiley: 755-769. https://doi.org/10.1002/1878-0261.12083.
dc.identifier.digitalEMT-and-MET
dc.identifier.doihttps://doi.org/10.1002/1878-0261.12083
dc.identifier.urihttps://hdl.handle.net/1911/97367
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordepithelial-to-mesenchymal transition
dc.subject.keywordhybrid epithelial/mesenchymal
dc.subject.keywordmesenchymal-to-epithelial transition
dc.subject.keywordmetastasis
dc.subject.keywordphenotypic plasticity
dc.titleEMT and MET: necessary or permissive for metastasis?
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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