EMT and MET: necessary or permissive for metastasis?

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dc.citation.firstpage755en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleMolecular Oncologyen_US
dc.citation.lastpage769en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorJolly, Mohit Kumaren_US
dc.contributor.authorWare, Kathryn E.en_US
dc.contributor.authorGilja, Shiveeen_US
dc.contributor.authorSomarelli, Jason A.en_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2017-08-21T14:34:15Zen_US
dc.date.available2017-08-21T14:34:15Zen_US
dc.date.issued2017en_US
dc.description.abstractEpithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.en_US
dc.identifier.citationJolly, Mohit Kumar, Ware, Kathryn E., Gilja, Shivee, et al.. "EMT and MET: necessary or permissive for metastasis?." <i>Molecular Oncology,</i> 11, no. 7 (2017) Wiley: 755-769. https://doi.org/10.1002/1878-0261.12083.en_US
dc.identifier.digitalEMT-and-METen_US
dc.identifier.doihttps://doi.org/10.1002/1878-0261.12083en_US
dc.identifier.urihttps://hdl.handle.net/1911/97367en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordepithelial-to-mesenchymal transitionen_US
dc.subject.keywordhybrid epithelial/mesenchymalen_US
dc.subject.keywordmesenchymal-to-epithelial transitionen_US
dc.subject.keywordmetastasisen_US
dc.subject.keywordphenotypic plasticityen_US
dc.titleEMT and MET: necessary or permissive for metastasis?en_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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