Exercise, inflammation, and fatigue in cancer survivors

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dc.citation.firstpage82en_US
dc.citation.journalTitleExercise Immunology Reviewen_US
dc.citation.lastpage93en_US
dc.citation.volumeNumber22en_US
dc.contributor.authorLaVoy, Emily C.P.en_US
dc.contributor.authorFagundes, Christopher P.en_US
dc.contributor.authorDantzer, Roberten_US
dc.date.accessioned2016-10-21T18:32:23Zen_US
dc.date.available2016-10-21T18:32:23Zen_US
dc.date.issued2016en_US
dc.description.abstractCancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer survivors are not yet fully understood, accumulating evidence suggests that several pathways, including chronic inflammation, autonomic imbalance, HPA-axis dysfunction, and/or mitochondrial damage, could contribute towards the disruption of normal neuronal function and result in the symptom of cancer-related fatigue. Exercise training interventions have been shown to be some of the more successful treatment options to address cancer-related fatigue. In this review, we discuss the literature regarding the causes of persistent fatigue in cancer survivors and the mechanisms by which exercise may relieve this symptom. There is still much work to be done until the prescription of exercise becomes standard practice for cancer survivors. With improvements in the quality of studies, evidenced-based exercise interventions will allow exercise scientists and oncologists to work together to treat cancer-related fatigue.en_US
dc.identifier.citationLaVoy, Emily C.P., Fagundes, Christopher P. and Dantzer, Robert. "Exercise, inflammation, and fatigue in cancer survivors." <i>Exercise Immunology Review,</i> 22, (2016) International Society of Exercise and Immunology: 82-93. <a href="https://hdl.handle.net/1911/91987">https://hdl.handle.net/1911/91987</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/91987en_US
dc.language.isoengen_US
dc.publisherInternational Society of Exercise and Immunologyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by International Society ofﾠExerciseﾠandﾠImmunology.en_US
dc.titleExercise, inflammation, and fatigue in cancer survivorsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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