An Evaluation of Perceived Health Risk and Depressive Symptoms Before a Disaster in Predicting Postdisaster Inflammation

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dc.citation.firstpage49
dc.citation.issueNumber1
dc.citation.journalTitlePsychosomatic Medicine
dc.citation.lastpage54
dc.citation.volumeNumber80
dc.contributor.authorMurdock, Kyle
dc.contributor.authorStowe, Raymond
dc.contributor.authorPeek, M.
dc.contributor.authorLawrence, Savannah
dc.contributor.authorFagundes, Christopher
dc.date.accessioned2019-12-11T15:44:25Z
dc.date.available2019-12-11T15:44:25Z
dc.date.issued2018
dc.description.abstractOBJECTIVE: Exposure to major life stressors is associated with subsequent enhanced inflammation-related disease processes. Depressive symptoms exacerbate stress-induced inflammatory responses. Moreover, those who report a high degree of perceived health risk before being exposed to a major life stressor such as a disaster are at risk for poor health outcomes. The present study examined whether perceived health risk and depressive symptoms before a disaster were associated with postdisaster inflammation markers. METHODS: The sample included 124 participants (mean [standard deviation] age = 55 [16] years; 69% women). At a baseline visit, participants completed self-report measures of perceived health risk and depressive symptoms (Center for Epidemiologic Studies Depression Scale) in addition to a blood draw for the assessment of inflammation markers (C-reactive protein, tumor necrosis factor receptor 1, and interleukin 6). All participants lived near a large petrochemical complex where an unexpected explosion occurred. A second blood sample was obtained 2 to 6 months after the explosion. RESULTS: No significant differences in inflammation markers were found between predisaster and postdisaster assessment (p > .21). An interaction between predisaster perceived health risk and depressive symptoms in predicting postdisaster circulating inflammation markers was identified (Cohen f = 0.051). Specifically, predisaster perceived health risk was associated with postdisaster circulating inflammation markers if predisaster depressive symptoms were greater than 8.10 on the Center for Epidemiologic Studies Depression Scale. CONCLUSIONS: These findings add to our understanding of the complex interactions between stress, depression, and immune responses. Indeed, findings provide a potential mechanism (i.e., inflammation) explaining the association between exposure to major life stressors and negative mental and physical health outcomes.
dc.identifier.citationMurdock, Kyle, Stowe, Raymond, Peek, M., et al.. "An Evaluation of Perceived Health Risk and Depressive Symptoms Before a Disaster in Predicting Postdisaster Inflammation." <i>Psychosomatic Medicine,</i> 80, no. 1 (2018) Wolters Kluwer: 49-54. https://doi.org/10.1097/PSY.0000000000000514.
dc.identifier.digitalnihms891938
dc.identifier.doihttps://doi.org/10.1097/PSY.0000000000000514
dc.identifier.urihttps://hdl.handle.net/1911/107855
dc.language.isoeng
dc.publisherWolters Kluwer
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wolters Kluwer
dc.titleAn Evaluation of Perceived Health Risk and Depressive Symptoms Before a Disaster in Predicting Postdisaster Inflammation
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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