Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

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dc.citation.firstpagee09623en_US
dc.citation.journalTitleeLifeen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorYou, Ranen_US
dc.contributor.authorLu, Wenen_US
dc.contributor.authorShan, Mingen_US
dc.contributor.authorBerlin, Jacob M.en_US
dc.contributor.authorSamuel, Errol L.G.en_US
dc.contributor.authorMarcano, Daniela C.en_US
dc.contributor.authorSun, Zhengzongen_US
dc.contributor.authorSikkema, William K.A.en_US
dc.contributor.authorYuan, Xiaoyien_US
dc.contributor.authorSong, Lizhenen_US
dc.contributor.authorHendrix, Amanda Y.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorCorry, David B.en_US
dc.contributor.authorKheradmand, Farrahen_US
dc.date.accessioned2016-01-15T19:47:52Zen_US
dc.date.available2016-01-15T19:47:52Zen_US
dc.date.issued2015en_US
dc.description.abstractChronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less known. In this study, we show that insoluble nanoparticulate carbon black (nCB) accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c+ lung antigen presenting cells (APC) of mice exposed to smoke. Likewise, nCB intranasal administration induced emphysema in mouse lungs. Delivered by smoking or intranasally, nCB persisted indefinitely in mouse lung, activated lung APCs, and promoted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflammasome assembly in phagocytes. Increasing the polarity or size of CB mitigated many adverse effects. Thus, nCB causes sterile inflammation, DSB, and emphysema and explains adverse health outcomes seen in smokers while implicating the dangers of nCB exposure in non-smokers.en_US
dc.identifier.citationYou, Ran, Lu, Wen, Shan, Ming, et al.. "Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema." <i>eLife,</i> 4, (2015) eLife Sciences Publications Ltd.: e09623. http://dx.doi.org/10.7554/eLife.09623.en_US
dc.identifier.doihttp://dx.doi.org/10.7554/eLife.09623en_US
dc.identifier.urihttps://hdl.handle.net/1911/87856en_US
dc.language.isoengen_US
dc.publishereLife Sciences Publications Ltd.en_US
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleNanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysemaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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