Modularity enhances the rate of evolution in a rugged fitness landscape

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dc.citation.firstpage25001en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitlePhysical Biologyen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorPark, Jeong-Manen_US
dc.contributor.authorChen, Manen_US
dc.contributor.authorWang, Dongen_US
dc.contributor.authorDeem, Michael W.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2016-06-24T21:35:01Zen_US
dc.date.available2016-06-24T21:35:01Zen_US
dc.date.issued2015en_US
dc.description.abstractBiological systems are modular, and this modularity affects the evolution of biological systems over time and in different environments. We here develop a theory for the dynamics of evolution in a rugged, modular fitness landscape. We show analytically how horizontal gene transfer couples to the modularity in the system and leads to more rapid rates of evolution at short times. The model, in general, analytically demonstrates a selective pressure for the prevalence of modularity in biology. We use this model to show how the evolution of the influenza virus is affected by the modularity of the proteins that are recognized by the human immune system. Approximately 25% of the observed rate of fitness increase of the virus could be ascribed to a modular viral landscape.en_US
dc.identifier.citationPark, Jeong-Man, Chen, Man, Wang, Dong, et al.. "Modularity enhances the rate of evolution in a rugged fitness landscape." <i>Physical Biology,</i> 12, no. 2 (2015) IOP Publishing Ltd: 025001. http://dx.doi.org/10.1088/1478-3975/12/2/025001.en_US
dc.identifier.doihttp://dx.doi.org/10.1088/1478-3975/12/2/025001en_US
dc.identifier.urihttps://hdl.handle.net/1911/90565en_US
dc.language.isoengen_US
dc.publisherIOP Publishing Ltden_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing Ltd.en_US
dc.titleModularity enhances the rate of evolution in a rugged fitness landscapeen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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