The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation

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dc.citation.firstpage777
dc.citation.issueNumber8
dc.citation.journalTitleTheranostics
dc.citation.lastpage787
dc.citation.volumeNumber2
dc.contributor.authorDanysh, Brian P.
dc.contributor.authorConstantinou, Pamela E.
dc.contributor.authorLukianova-Hleb, Ekaterina Y.
dc.contributor.authorLapotko, Dmitri O.
dc.contributor.authorCarson, Daniel D.
dc.date.accessioned2012-10-30T21:24:57Z
dc.date.available2012-10-30T21:24:57Z
dc.date.issued2012
dc.description.abstractMUC1 is a large, heavily glycosylated transmembrane glycoprotein that is proposed to create a protective microenvironment in many adenocarcinomas. Here we compare MUC1 and the well studied cell surface receptor target, EGFR, as gold nanoparticle (AuNP) targets and their subsequent vapor nanobubble generation efficacy in the human epithelial cell line, HES. Although EGFR and MUC1 were both highly expressed in these cells, TEM and confocal images revealed MUC1 as a superior target for nanoparticle intracellular accumulation and clustering. The MUC1-targeted AuNP intracellular clusters also generated significantly larger vapor nanobubbles. Our results demonstrate the promising opportunities MUC1 offers to improve the efficacy of targeted nanoparticle based approaches.
dc.identifier.citationDanysh, Brian P., Constantinou, Pamela E., Lukianova-Hleb, Ekaterina Y., et al.. "The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation." <i>Theranostics,</i> 2, no. 8 (2012) Ivyspring International Publisher: 777-787. http://dx.doi.org/10.7150/thno.4494.
dc.identifier.doihttp://dx.doi.org/10.7150/thno.4494
dc.identifier.urihttps://hdl.handle.net/1911/64881
dc.language.isoeng
dc.publisherIvyspring International Publisher
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keywordMUC1
dc.subject.keywordEGFR
dc.subject.keywordtargeted gold nanoparticle
dc.subject.keywordvapor nanobubble
dc.subject.keywordnanoparticle endocytosis
dc.subject.keywordnanoparticle clustering
dc.titleThe MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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