The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation

Simple item page
dc.citation.firstpage777en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleTheranosticsen_US
dc.citation.lastpage787en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorDanysh, Brian P.en_US
dc.contributor.authorConstantinou, Pamela E.en_US
dc.contributor.authorLukianova-Hleb, Ekaterina Y.en_US
dc.contributor.authorLapotko, Dmitri O.en_US
dc.contributor.authorCarson, Daniel D.en_US
dc.date.accessioned2012-10-30T21:24:57Zen_US
dc.date.available2012-10-30T21:24:57Zen_US
dc.date.issued2012en_US
dc.description.abstractMUC1 is a large, heavily glycosylated transmembrane glycoprotein that is proposed to create a protective microenvironment in many adenocarcinomas. Here we compare MUC1 and the well studied cell surface receptor target, EGFR, as gold nanoparticle (AuNP) targets and their subsequent vapor nanobubble generation efficacy in the human epithelial cell line, HES. Although EGFR and MUC1 were both highly expressed in these cells, TEM and confocal images revealed MUC1 as a superior target for nanoparticle intracellular accumulation and clustering. The MUC1-targeted AuNP intracellular clusters also generated significantly larger vapor nanobubbles. Our results demonstrate the promising opportunities MUC1 offers to improve the efficacy of targeted nanoparticle based approaches.en_US
dc.identifier.citationDanysh, Brian P., Constantinou, Pamela E., Lukianova-Hleb, Ekaterina Y., et al.. "The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation." <i>Theranostics,</i> 2, no. 8 (2012) Ivyspring International Publisher: 777-787. http://dx.doi.org/10.7150/thno.4494.en_US
dc.identifier.doihttp://dx.doi.org/10.7150/thno.4494en_US
dc.identifier.urihttps://hdl.handle.net/1911/64881en_US
dc.language.isoengen_US
dc.publisherIvyspring International Publisheren_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.subject.keywordMUC1en_US
dc.subject.keywordEGFRen_US
dc.subject.keywordtargeted gold nanoparticleen_US
dc.subject.keywordvapor nanobubbleen_US
dc.subject.keywordnanoparticle endocytosisen_US
dc.subject.keywordnanoparticle clusteringen_US
dc.titleThe MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thnov02p0777.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry and Cell Biology Publications
Faculty Publications
Physics and Astronomy Publications