Simple differential digital confocal aperture to improve axial response of line-scanning confocal microendoscopes

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dc.citation.firstpage4519en_US
dc.citation.issueNumber18en_US
dc.citation.journalTitleOptics Lettersen_US
dc.citation.lastpage4522en_US
dc.citation.volumeNumber44en_US
dc.contributor.authorTang, Yuboen_US
dc.contributor.authorKortum, Alexen_US
dc.contributor.authorVohra, Imranen_US
dc.contributor.authorCarns, Jenniferen_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2019-10-23T15:55:35Zen_US
dc.date.available2019-10-23T15:55:35Zen_US
dc.date.issued2019en_US
dc.description.abstractLine-scanning confocal microendoscopy offers video-rate cellular imaging of scattering tissue with relatively simple hardware, but its axial response is inferior to that of point-scanning systems. Based on Fourier optics theory, we designed differential confocal apertures with a simple subtraction technique to improve the line-scanning sectioning performance. Taking advantage of digital slit apertures on a digital light projector and a CMOS rolling shutter, we demonstrate real-time optical sectioning performance comparable to point scanning in a dual-camera microendoscope (<$6,000). We validate the background rejection capability when imaging porcine columnar epithelium stained with fluorescent contrast agents with different uptake mechanisms and staining properties.en_US
dc.identifier.citationTang, Yubo, Kortum, Alex, Vohra, Imran, et al.. "Simple differential digital confocal aperture to improve axial response of line-scanning confocal microendoscopes." <i>Optics Letters,</i> 44, no. 18 (2019) Optical Society of America: 4519-4522. https://doi.org/10.1364/OL.44.004519.en_US
dc.identifier.doihttps://doi.org/10.1364/OL.44.004519en_US
dc.identifier.urihttps://hdl.handle.net/1911/107499en_US
dc.language.isoengen_US
dc.publisherOptical Society of Americaen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Optical Society of America.en_US
dc.titleSimple differential digital confocal aperture to improve axial response of line-scanning confocal microendoscopesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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