Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

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dc.citation.firstpage1en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleJournal of Alzheimer’s Diseaseen_US
dc.citation.lastpage10en_US
dc.citation.volumeNumber60en_US
dc.contributor.authorIghodaro, Eseosa T.en_US
dc.contributor.authorNelson, Peter T.en_US
dc.contributor.authorKukull, Walter A.en_US
dc.contributor.authorSchmitt, Frederick A.en_US
dc.contributor.authorAbner, Erin L.en_US
dc.contributor.authorCaban-Holt, Allisonen_US
dc.contributor.authorBardach, Shoshana H.en_US
dc.contributor.authorHord, Derrick C.en_US
dc.contributor.authorGlover, Crystal M.en_US
dc.contributor.authorJicha, Gregory A.en_US
dc.contributor.authorVan Eldik, Linda J.en_US
dc.contributor.authorByrd, Alexander X.en_US
dc.contributor.authorFernander, Anitaen_US
dc.date.accessioned2017-11-15T14:12:33Zen_US
dc.date.available2017-11-15T14:12:33Zen_US
dc.date.issued2017en_US
dc.description.abstractBlacks/African Americans have been reported to be ∼2–4 times more likely to develop clinical Alzheimer’s disease (AD) compared to Whites. Unfortunately, study design challenges (e.g., recruitment bias), racism, mistrust of healthcare providers and biomedical researchers, confounders related to socioeconomic status, and other sources of bias are often ignored when interpreting differences in human subjects categorized by race. Failure to account for these factors can lead to misinterpretation of results, reification of race as biology, discrimination, and missed or delayed diagnoses. Here we provide a selected historical background, discuss challenges, present opportunities, and suggest considerations for studying health outcomes among racial/ethnic groups. We encourage neuroscientists to consider shifting away from using biologic determination to interpret data, and work instead toward a paradigm of incorporating both biological and socio-environmental factors known to affect health outcomes with the goal of understanding and improving dementia treatments for Blacks/African Americans and other underserved populations.en_US
dc.identifier.citationIghodaro, Eseosa T., Nelson, Peter T., Kukull, Walter A., et al.. "Challenges and Considerations Related to Studying Dementia in Blacks/African Americans." <i>Journal of Alzheimer’s Disease,</i> 60, no. 1 (2017) IOS Press: 1-10. https://doi.org/10.3233/JAD-170242.en_US
dc.identifier.digitalJAD_2017_Ighodaro_et_al_Dementia_research_on_African_Americansen_US
dc.identifier.doihttps://doi.org/10.3233/JAD-170242en_US
dc.identifier.urihttps://hdl.handle.net/1911/98816en_US
dc.language.isoengen_US
dc.publisherIOS Pressen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOS Press.en_US
dc.subject.keywordAutopsyen_US
dc.subject.keywordepidemiologyen_US
dc.subject.keywordethnicityen_US
dc.subject.keywordneurodegenerativeen_US
dc.subject.keywordneuropathologyen_US
dc.titleChallenges and Considerations Related to Studying Dementia in Blacks/African Americansen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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