Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors

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dc.citation.firstpage976en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleTheranosticsen_US
dc.citation.lastpage987en_US
dc.citation.volumeNumber2en_US
dc.contributor.authorLukianova-Hleb, Ekaterina Y.en_US
dc.contributor.authorRen, Xiaoyangen_US
dc.contributor.authorTownley, Debraen_US
dc.contributor.authorWu, Xiangweien_US
dc.contributor.authorKupferman, Michael E.en_US
dc.date.accessioned2013-01-09T19:09:50Zen_US
dc.date.available2013-01-09T19:09:50Zen_US
dc.date.issued2012en_US
dc.description.abstractThe resistance of residual cancer cells after oncological resection to adjuvant chemoradiotherapies results in both high recurrence rates and high non-specific tissue toxicity, thus preventing the successful treatment of such cancers as head and neck squamous cell carcinoma (HNSCC). The patients' survival rate and quality of life therefore depend upon the efficacy, selectivity and low non-specific toxicity of the adjuvant treatment. We report a novel, theranostic in vivo technology that unites both the acoustic diagnostics and guided intracellular delivery of anti-tumor drug (liposome-encapsulated doxorubicin, Doxil) in one rapid process, namely a pulsed laser-activated plasmonic nanobubble (PNB). HNSCC-bearing mice were treated with gold nanoparticle conjugates, Doxil, and single near-infrared laser pulses of low energy. Tumor-specific clusters of gold nanoparticles (solid gold spheres) converted the optical pulses into localized PNBs. The acoustic signals of the PNB detected the tumor with high specificity and sensitivity. The mechanical impact of the PNB, co-localized with Doxil liposomes, selectively ejected the drug into the cytoplasm of cancer cells. Cancer cell-specific generation of PNBs and their intracellular co-localization with Doxil improved the in vivo therapeutic efficacy from 5-7% for administration of only Doxil or PNBs alone to 90% thus demonstrating the synergistic therapeutic effect of the PNB-based intracellular drug release. This mechanism also reduced the non-specific toxicity of Doxil below a detectable level and the treatment time to less than one minute. Thus PNBs combine highly sensitive diagnosis, overcome drug resistance and minimize non-specific toxicity in a single rapid theranostic procedure for intra-operative treatment.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationLukianova-Hleb, Ekaterina Y., Ren, Xiaoyang, Townley, Debra, et al.. "Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors." <i>Theranostics,</i> 2, no. 10 (2012) Ivyspring International Publisher: 976-987. http://dx.doi.org/10.7150/thno.5116.en_US
dc.identifier.doihttp://dx.doi.org/10.7150/thno.5116en_US
dc.identifier.urihttps://hdl.handle.net/1911/68530en_US
dc.language.isoengen_US
dc.publisherIvyspring International Publisheren_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titlePlasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumorsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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