Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors

Simple item page
dc.citation.firstpage976
dc.citation.issueNumber10
dc.citation.journalTitleTheranostics
dc.citation.lastpage987
dc.citation.volumeNumber2
dc.contributor.authorLukianova-Hleb, Ekaterina Y.
dc.contributor.authorRen, Xiaoyang
dc.contributor.authorTownley, Debra
dc.contributor.authorWu, Xiangwei
dc.contributor.authorKupferman, Michael E.
dc.date.accessioned2013-01-09T19:09:50Z
dc.date.available2013-01-09T19:09:50Z
dc.date.issued2012
dc.description.abstractThe resistance of residual cancer cells after oncological resection to adjuvant chemoradiotherapies results in both high recurrence rates and high non-specific tissue toxicity, thus preventing the successful treatment of such cancers as head and neck squamous cell carcinoma (HNSCC). The patients' survival rate and quality of life therefore depend upon the efficacy, selectivity and low non-specific toxicity of the adjuvant treatment. We report a novel, theranostic in vivo technology that unites both the acoustic diagnostics and guided intracellular delivery of anti-tumor drug (liposome-encapsulated doxorubicin, Doxil) in one rapid process, namely a pulsed laser-activated plasmonic nanobubble (PNB). HNSCC-bearing mice were treated with gold nanoparticle conjugates, Doxil, and single near-infrared laser pulses of low energy. Tumor-specific clusters of gold nanoparticles (solid gold spheres) converted the optical pulses into localized PNBs. The acoustic signals of the PNB detected the tumor with high specificity and sensitivity. The mechanical impact of the PNB, co-localized with Doxil liposomes, selectively ejected the drug into the cytoplasm of cancer cells. Cancer cell-specific generation of PNBs and their intracellular co-localization with Doxil improved the in vivo therapeutic efficacy from 5-7% for administration of only Doxil or PNBs alone to 90% thus demonstrating the synergistic therapeutic effect of the PNB-based intracellular drug release. This mechanism also reduced the non-specific toxicity of Doxil below a detectable level and the treatment time to less than one minute. Thus PNBs combine highly sensitive diagnosis, overcome drug resistance and minimize non-specific toxicity in a single rapid theranostic procedure for intra-operative treatment.
dc.embargo.termsnone
dc.identifier.citationLukianova-Hleb, Ekaterina Y., Ren, Xiaoyang, Townley, Debra, et al.. "Plasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors." <i>Theranostics,</i> 2, no. 10 (2012) Ivyspring International Publisher: 976-987. http://dx.doi.org/10.7150/thno.5116.
dc.identifier.doihttp://dx.doi.org/10.7150/thno.5116
dc.identifier.urihttps://hdl.handle.net/1911/68530
dc.language.isoeng
dc.publisherIvyspring International Publisher
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titlePlasmonic Nanobubbles Rapidly Detect and Destroy Drug-Resistant Tumors
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Plasmonic-nanobubbles.pdf
Size:
1.51 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry and Cell Biology Publications
Faculty Publications
Physics and Astronomy Publications