Development of modularity in the neural activity of childrenʼs brains

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dc.citation.articleNumber16009en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitlePhysical Biologyen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorChen, Manen_US
dc.contributor.authorDeem, Michael W.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2017-05-22T18:57:18Zen_US
dc.date.available2017-05-22T18:57:18Zen_US
dc.date.issued2015en_US
dc.description.abstractWe study how modularity of the human brain changes as children develop into adults. Theory suggests that modularity can enhance the response function of a networked system subject to changing external stimuli. Thus, greater cognitive performance might be achieved for more modular neural activity, and modularity might likely increase as children develop. The value of modularity calculated from functional magnetic resonance imaging (fMRI) data is observed to increase during childhood development and peak in young adulthood. Head motion is deconvolved from the fMRI data, and it is shown that the dependence of modularity on age is independent of the magnitude of head motion. A model is presented to illustrate how modularity can provide greater cognitive performance at short times, i.e. task switching. A fitness function is extracted from the model. Quasispecies theory is used to predict how the average modularity evolves with age, illustrating the increase of modularity during development from children to adults that arises from selection for rapid cognitive function in young adults. Experiments exploring the effect of modularity on cognitive performance are suggested. Modularity may be a potential biomarker for injury, rehabilitation, or disease.en_US
dc.identifier.citationChen, Man and Deem, Michael W.. "Development of modularity in the neural activity of childrenʼs brains." <i>Physical Biology,</i> 12, no. 1 (2015) IOP Publishing: https://doi.org/10.1088/1478-3975/12/1/016009.en_US
dc.identifier.doihttps://doi.org/10.1088/1478-3975/12/1/016009en_US
dc.identifier.urihttps://hdl.handle.net/1911/94328en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by IOP Publishing.en_US
dc.titleDevelopment of modularity in the neural activity of childrenʼs brainsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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