How input noise limits biochemical sensing in ultrasensitive systems

Simple item page
dc.citation.firstpage32702
dc.citation.journalTitlePhysical Review E
dc.citation.volumeNumber90
dc.contributor.authorHu, Bo
dc.contributor.authorRappel, Wouter-Jan
dc.contributor.authorLevine, Herbert
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2014-10-30T19:33:32Z
dc.date.available2014-10-30T19:33:32Z
dc.date.issued2014
dc.description.abstractMany biological processes are regulated by molecular devices that respond in an ultrasensitive fashion to upstream signals. An important question is whether such ultrasensitivity improves or limits its ability to read out the (noisy) input stimuli. Here, we develop a simple model to study the statistical properties of ultrasensitive signaling systems. We demonstrate that the output sensory noise is always bounded, in contrast to earlier theories using the small noise approximation, which tends to overestimate the impact of noise in ultrasensitive pathways. Our analysis also shows that the apparent sensitivity of the system is ultimately constrained by the input signal-to-noise ratio. Thus, ultrasensitivity can improve the precision of biochemical sensing only to a finite extent. This corresponds to a new limit for ultrasensitive signaling systems, which is strictly tighter than the Berg-Purcell limit.
dc.identifier.citationHu, Bo, Rappel, Wouter-Jan and Levine, Herbert. "How input noise limits biochemical sensing in ultrasensitive systems." <i>Physical Review E,</i> 90, (2014) American Physical Society: 32702. http://dx.doi.org/10.1103/PhysRevE.90.032702.
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.90.032702
dc.identifier.urihttps://hdl.handle.net/1911/77670
dc.language.isoeng
dc.publisherAmerican Physical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleHow input noise limits biochemical sensing in ultrasensitive systems
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
PhysRevE.90.032702.pdf
Size:
446.83 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Physics and Astronomy Publications