Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater

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dc.citation.articleNumber2834
dc.citation.journalTitleNature Communications
dc.citation.volumeNumber14
dc.contributor.authorSapoval, Nicolae
dc.contributor.authorLiu, Yunxi
dc.contributor.authorLou, Esther G.
dc.contributor.authorHopkins, Loren
dc.contributor.authorEnsor, Katherine B.
dc.contributor.authorSchneider, Rebecca
dc.contributor.authorStadler, Lauren B.
dc.contributor.authorTreangen, Todd J.
dc.date.accessioned2023-07-21T16:14:05Z
dc.date.available2023-07-21T16:14:05Z
dc.date.issued2023
dc.description.abstractAs clinical testing declines, wastewater monitoring can provide crucial surveillance on the emergence of SARS-CoV-2 variant of concerns (VoCs) in communities. In this paper we present QuaID, a novel bioinformatics tool for VoC detection based on quasi-unique mutations. The benefits of QuaID are three-fold: (i) provides up to 3-week earlier VoC detection, (ii) accurate VoC detection (>95% precision on simulated benchmarks), and (iii) leverages all mutational signatures (including insertions & deletions).
dc.identifier.citationSapoval, Nicolae, Liu, Yunxi, Lou, Esther G., et al.. "Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater." <i>Nature Communications,</i> 14, (2023) Springer Nature: https://doi.org/10.1038/s41467-023-38184-3.
dc.identifier.digitals41467-023-38184-3
dc.identifier.doihttps://doi.org/10.1038/s41467-023-38184-3
dc.identifier.urihttps://hdl.handle.net/1911/115014
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleEnabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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